Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients.
Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients.
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DOI：
10.4161/oxim.2.2.8160
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发表时间：
2009-04
影响因子：
--
通讯作者：
Misra MK
中科院分区：
文献类型：
--
作者：
Gupta A;Bhatt ML;Misra MK
氧化应激是活性氧形成和失活之间失衡的结果，可能参与许多疾病包括癌症的发病机制。为了评估氧化应激的程度，在开始任何肿瘤治疗之前，对头颈部鳞状细胞癌患者的超氧化物歧化酶、总硫醇、抗坏血酸和丙二醛（MDA）的血浆水平进行了研究，并与健康对照组进行了比较。恶性肿瘤患者超氧化物歧化酶比活力明显低于正常人（P < 0.05）。总巯基和抗坏血酸水平显著降低（p < 0.005），而患者中MDA水平显著增加（p < 0.00005）。我们的研究结果表明，氧化应激在癌症患者中升高，这可以通过脂质过氧化产物水平升高以及酶和非酶抗氧化剂的消耗来证明。
Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head and neck squamous cell carcinoma patients before the start of any oncological treatment and compared with healthy controls. The specific activity of superoxide dismutase in cancer patients is decreased significantly when compared to the control (p < 0.05). The total thiol and ascorbic acid levels are significantly reduced (p < 0.005) whereas MDA levels are significantly increased in the patients (p < 0.00005). Our findings show that the oxidative stress is elevated in cancer patients as evidenced by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants.
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影响因子：
168.9
作者：
CERUTTI, PA
通讯作者：
CERUTTI, PA
影响因子：
2.8
作者：
Seven, A;Civelek, S;Burçak, G
通讯作者：
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作者：
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通讯作者：
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DOI：
10.1080/15287390590967478
发表时间：
2005-09-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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作者：
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