Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua.
Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua.
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DOI：
10.1086/648592
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Harris E
中科院分区：
文献类型：
--
作者：
Balmaseda A;Standish K;Mercado JC;Matute JC;Tellez Y;Saborío S;Hammond SN;Nuñez A;Avilés W;Henn MR;Holmes EC;Gordon A;Coloma J;Kuan G;Harris E
Dengue is the most prevalent mosquito-borne viral disease in humans and a major urban public health problem worldwide. A prospective cohort study of ~3,800 children initially aged 2-9 years old was established in Managua, Nicaragua, in 2004 to study the natural history of dengue transmission in an urban pediatric population. Blood samples from healthy subjects were collected annually prior to the dengue season, and identification of dengue cases occurred via enhanced passive surveillance at the study health center. Over the first four years of the study, seroprevalence of anti-dengue virus (DENV) antibodies increased from 22-40% in the 2-year-old cohort and 90-95% in the 9-year-old cohort. The incidence of symptomatic dengue cases and the ratio of inapparent to symptomatic DENV infection varied substantially year-to-year. The switch in dominant transmission from DENV-1 to DENV-2 was accompanied by an increase in disease severity but, paradoxically, a decrease in transmission. Phylogeographic analysis of full-length DENV-2 sequences revealed strong geographic clustering of dengue cases. This large-scale cohort study of dengue in the Americas demonstrates year-to-year variation of dengue within a pediatric population, revealing expected patterns in transmission while highlighting the impact of interventions, climate, and viral evolution.
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影响因子：
15.8
作者：
Avilés W;Ortega O;Kuan G;Coloma J;Harris E
通讯作者：
Harris E
影响因子：
5
作者：
Endy, TP;Chunsuttiwat, S;Ennis, FA
通讯作者：
Ennis, FA
DOI：
10.4269/ajtmh.1969.18.997
发表时间：
1969-01-01
影响因子：
3.3
作者：
HALSTEAD, SB;SCANLON, JE;UDOMSAKDI, S
通讯作者：
UDOMSAKDI, S
DOI：
10.4269/ajtmh.1988.38.172
发表时间：
1988-01-01
影响因子：
3.3
作者：
BURKE, DS;NISALAK, A;SCOTT, RM
通讯作者：
SCOTT, RM
影响因子：
4.3
作者：
Akram, Dure Samin;Igarashi, Akira;Takasu, T.
通讯作者：
Takasu, T.