Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.
Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.
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DOI：
10.1084/jem.20131666
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发表时间：
2014-06-30
期刊：
影响因子：
--
通讯作者：
Okada T
中科院分区：
文献类型：
--
作者：
Moriyama S;Takahashi N;Green JA;Hori S;Kubo M;Cyster JG;Okada T
S1 PR 2和CXCR 5协同调节Tfh细胞在GC中的定位以支持GC应答。滤泡辅助T（Tfh）细胞进入B细胞滤泡以促进抗体应答，并且对于生发中心（GC）反应特别重要。然而，Tfh细胞如何与GC物理相关的分子机制尚未完全了解。我们报告说，鞘氨醇-1-磷酸受体2（S1 PR 2）基因是高度表达的Tfh细胞，定位在GC的亚群。S1 PR 2缺陷型Tfh细胞由于其保留受损而在GC中的蓄积减少。与仅缺乏CXCR 5的T细胞相比，缺乏S1 PR 2和CXCR 5的T细胞在支持GC应答方面是无效的。这些结果表明，S1 PR 2和CXCR 5协同调节Tfh细胞在GC中的定位以支持GC应答。
S1PR2 and CXCR5 cooperatively regulate localization of Tfh cells in GCs to support GC responses. Follicular helper T (Tfh) cells access the B cell follicle to promote antibody responses and are particularly important for germinal center (GC) reactions. However, the molecular mechanisms of how Tfh cells are physically associated with GCs are incompletely understood. We report that the sphingosine-1-phosphate receptor 2 (S1PR2) gene is highly expressed in a subpopulation of Tfh cells that localizes in GCs. S1PR2-deficient Tfh cells exhibited reduced accumulation in GCs due to their impaired retention. T cells deficient in both S1PR2 and CXCR5 were ineffective in supporting GC responses compared with T cells deficient only in CXCR5. These results suggest that S1PR2 and CXCR5 cooperatively regulate localization of Tfh cells in GCs to support GC responses.
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DOI：
10.1084/jem.20111449
发表时间：
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期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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