Noninvasive quantification of regional myocardial metabolic rate for oxygen by use of 15O2 inhalation and positron emission tomography. Theory, error analysis, and application in humans.
Noninvasive quantification of regional myocardial metabolic rate for oxygen by use of 15O2 inhalation and positron emission tomography. Theory, error analysis, and application in humans.
复制标题
使用 15O2 吸入和正电子发射断层扫描对局部心肌氧代谢率进行无创定量。
作者：
Hidehiro Iida;Christopher G. Rhodes;Luis I. Araujo;Yusuke Yamamoto;Ranil de Silva;A. Maseri;T. Jones
背景
已经开发出一种通过使用 15O2 吸入和正电子发射断层扫描来定量、无创地测量人体局部心肌耗氧代谢率 (rMMRO2) 和氧提取分数 (rOEF) 的方法。本文介绍了人体可行性研究中使用的理论、技术误差分析和程序。
方法和结果
吸入的15O2被输送到周围组织，转化为15O标记的代谢水，与较大的血管外组织空间进行交换。对这种放射性积累的定量可以计算 rMMRO2 和 rOEF。然而，需要对肺部气体放射性信号溢出到心肌区域进行校正，并且已经通过使用从透射扫描估计的气体体积分布来进行校正。使用惰性气体 [11C]CH4 对四只灰狗进行比较测量，验证了这一点。心室放射性的溢出已通过吸入[13O]CO（血容量）扫描进行校正。由于室壁运动和厚度而对心肌放射性的低估已通过使用从流量测量[15OKCO2 扫描]获得的组织分数值进行了校正。无论是从透射数据还是 [11C]CH4 扫描数据确定的气体体积测量中获得的 rOEF 值都相似（在 4% 以内）。六名健康志愿者的 15O2 扫描信息显示，扣除血管和肺部气体 15O 背景后，心肌放射性分布清晰。随后的区室分析得出静息时人心肌中 rOEF 和 rMMRO2 的值为 0.60 +/- 0.11 和 0.10 +/- 0.03 mL.min-1.g-1。
结论
这项研究的结果与既定值非常吻合。这是第一个已知的方法，可以在区域内无创地直接定量测定 rOEF 和氧代谢。
BACKGROUND
A method has been developed to measure the regional myocardial metabolic rate of oxygen consumption (rMMRO2) and oxygen extraction fraction (rOEF) quantitatively and noninvasively in humans by use of 15O2 inhalation and positron emission tomography. This article describes the theory, an error analysis of the technique, and procedures of the method used in a human feasibility study.
METHODS AND RESULTS
Inhaled 15O2 is transported to peripheral tissues, where it is converted to 15O-labeled water of metabolism, which exchanges with the relatively large extravascular tissue space. Quantification of this buildup of radioactivity allows the calculation of rMMRO2 and rOEF. However, a correction for the spillover of the pulmonary gas radioactivity signal into myocardial regions is required and has been made by use of a gas volume distribution estimated from the transmission scan. This was validated by comparative measurements using the inert gas [11C]CH4 in four greyhounds. Spillover of the cardiac chamber radioactivity has been corrected for with an inhaled [13O]CO (blood volume) scan. The underestimation of myocardial radioactivity due to wall motion and thickness has been corrected for by use of values of tissue fraction obtained from the flow measurement [15OKCO2 scan). Values of rOEF were similar (within 4%) whether obtained from gas volume measurements determined from the transmission or [11C]CH4 scan data. 15O2 scan information from six healthy volunteers showed a clear distribution of myocardial radioactivity after the vascular and pulmonary gas 15O background was subtracted. Subsequent compartmental analysis resulted in values for rOEF and rMMRO2 of 0.60 +/- 0.11 and 0.10 +/- 0.03 mL.min-1.g-1 in the human myocardium at rest.
CONCLUSIONS
The results of this study are in good agreement with established values. This is the first known approach to allow the direct quantitative determination of rOEF and oxygen metabolism to be made noninvasively on a regional basis.
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用醋酸碳 11 和正电子发射断层扫描对犬心肌氧化代谢进行无创评估。
影响因子：
24
作者：
Brown,MA;Myears,DW;Bergmann,SR
通讯作者：
Bergmann,SR
使用[1-11C]乙酸盐和动态正电子发射断层扫描对体内局部心肌耗氧量进行无创定量。
影响因子：
37.8
作者：
Buxton,DB;Nienaber,CA;Luxen,A;Ratib,O;Hansen,H;Phelps,ME;Schelbert,HR
通讯作者：
Schelbert,HR
尽管底物利用模式改变，但用碳 11 醋酸盐和正电子发射断层扫描评估心肌氧化代谢的有效性。
DOI：
--
发表时间：
1989
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Brown,MA;Myears,DW;Bergmann,SR
通讯作者：
Bergmann,SR
DOI：
--
发表时间：
2006
期刊：
--
影响因子：
--
作者：
M. Mintun;M. Raichle;W. Martin
通讯作者：
M. Mintun;M. Raichle;W. Martin
影响因子：
37.8
作者：
BROWN, M;MARSHALL, DR;BERGMANN, SR
通讯作者：
BERGMANN, SR