Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort study.
Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort study.
复制标题
DOI：
10.1136/bmj.e5414
复制
发表时间：
2012-08-29
期刊：
影响因子：
--
通讯作者：
Lan Q
中科院分区：
文献类型：
--
作者：
Barone-Adesi F;Chapman RS;Silverman DT;He X;Hu W;Vermeulen R;Ning B;Fraumeni JF Jr;Rothman N;Lan Q
目的评估使用不同类型煤进行家庭烹饪和取暖与肺癌的相关性。中国云南省宣威县。研究设计：回顾性队列研究（随访1976-96），比较终生使用“无烟煤”（无烟煤）和“无烟煤”（烟煤）的肺癌死亡率。研究对象为27310名终生使用无烟煤的个体和9962名终生使用无烟煤的个体。主要结果测量主要结果是不同类型煤炭使用者肺癌死亡的绝对和相对风险。未校正的生存分析被用来估计肺癌的绝对风险，而考克斯回归模型比较了吸烟和无烟煤用户之间的肺癌死亡风险。结果煤烟型居民肺癌死亡率明显高于无烟煤居民。使用煤烟的男性和女性在70岁之前肺癌死亡的绝对风险分别为18%和20%，而无烟煤使用者的男性和女性的绝对风险均小于0.5%。在60岁之前的所有使用煤烟的人中，肺癌一项就占了大约40%。与无烟煤相比，使用无烟煤与肺癌死亡风险增加有关（男性，风险比为36（95%置信区间为20至65）;女性，99（37至266））。结论在宣威市，家庭使用煤烟与肺癌绝对终生风险的大幅增加有关，可能是环境污染对癌症风险的最强影响之一。使用致癌性较低的煤可以大幅降低肺癌风险。
Objective To estimate the risk of lung cancer associated with the use of different types of coal for household cooking and heating. Setting Xuanwei County, Yunnan Province, China. Design Retrospective cohort study (follow-up 1976-96) comparing mortality from lung cancer between lifelong users of “smoky coal” (bituminous) and “smokeless coal” (anthracite). Participants 27 310 individuals using smoky coal and 9962 individuals using smokeless coal during their entire life. Main outcome measures Primary outcomes were absolute and relative risk of death from lung cancer among users of different types of coal. Unadjusted survival analysis was used to estimate the absolute risk of lung cancer, while Cox regression models compared mortality hazards for lung cancer between smoky and smokeless coal users. Results Lung cancer mortality was substantially higher among users of smoky coal than users of smokeless coal. The absolute risks of lung cancer death before 70 years of age for men and women using smoky coal were 18% and 20%, respectively, compared with less than 0.5% among smokeless coal users of both sexes. Lung cancer alone accounted for about 40% of all deaths before age 60 among individuals using smoky coal. Compared with smokeless coal, use of smoky coal was associated with an increased risk of lung cancer death (for men, hazard ratio 36 (95% confidence interval 20 to 65); for women, 99 (37 to 266)). Conclusions In Xuanwei, the domestic use of smoky coal is associated with a substantial increase in the absolute lifetime risk of developing lung cancer and is likely to represent one of the strongest effects of environmental pollution reported for cancer risk. Use of less carcinogenic types of coal could translate to a substantial reduction of lung cancer risk.
登录
查看更多内容
影响因子：
10.4
作者：
Shen M;Chapman RS;Vermeulen R;Tian L;Zheng T;Chen BE;Engels EA;He X;Blair A;Lan Q
通讯作者：
Lan Q
影响因子：
8.8
作者：
Hosgood, H. D., III;Chapman, R.;Shen, M.;Blair, A.;Chen, E.;Zheng, T.;Lee, K-M;He, X.;Lan, Q.
通讯作者：
Lan, Q.
影响因子：
2
作者：
PEPE, MS;MORI, M
通讯作者：
MORI, M
影响因子：
8.8
作者：
Crispo, A;Brennan, P;Darby, S
通讯作者：
Darby, S
DOI：
10.1093/jnci/94.11.826
发表时间：
2002-06-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Lan, Q;Chapman, RS;He, XZ
通讯作者：
He, XZ