Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users.

Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users.
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DOI:
10.1038/sj.bjc.6604744
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发表时间:
2008-12-02
影响因子:
8.8
通讯作者:
Lan, Q.
Lan, Q.
中科院分区:
医学1区
文献类型:
--
作者:
Hosgood, H. D., III;Chapman, R.;Shen, M.;Blair, A.;Chen, E.;Zheng, T.;Lee, K-M;He, X.;Lan, Q.

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全球约有30亿人暴露于烹饪和取暖产生的家庭燃料燃烧,这与肺癌风险增加有关。宣威肺癌发病率最高的是中国,燃煤不排烟导致肺癌的归因风险大于90%。为了评估从无通风炉灶改为便携式炉灶后肺癌死亡率的下降情况,我们对1917-1951年出生并于1976年居住在宣威的所有农民进行了终身烟雾煤使用者的回顾队列。在42名 422注册的农民中,4,054名终生使用烟煤的人改用便携式炉具,4,364人没有改变,1,074人死于肺癌。通过产品极限生存曲线和多变量COX回归模型评估与炉灶改变相关的肺癌死亡率。无论是男性(P<0.0001)还是女性(P<0.0001),与没有改变的人相比,改用便携式炉具的存活率显著增加。在男性参与者(风险比(HR)=0.62,95%可信区间(CI)=0.46-0.82)和女性参与者(HR=0.41,95%CI=0.29-0.57)中,便携式炉具与肺癌死亡风险降低相关。便携式炉灶的使用与降低肺癌死亡风险有关,这突显了一种成本效益高的干预措施,可以极大地造福发展中国家的健康。
Domestic fuel combustion from cooking and heating, to which about 3 billion people worldwide are exposed, is associated with increased lung cancer risk. Lung cancer incidence in Xuanwei is the highest in China, and the attributable risk of lung cancer from unvented smoky coal burning is greater than 90%. To evaluate any lung cancer mortality reduction after changing from unvented stoves to portable stoves, we used lifetime smoky coal users in a retrospective cohort of all farmers born during 1917–1951 and residing in Xuanwei in 1976. Of the 42 422 enrolled farmers, 4054 lifetime smoky coal users changed to portable stoves, 4364 did not change, and 1074 died of lung cancer. Lung cancer morality associated with stove change was assessed by product-limit survival curves and multivariate Cox regression models. Both men (P<0.0001) and women (P<0.0001) who changed to portable stoves had a significantly increased probability of survival compared with those who did not change. Portable stoves were associated with decreased risk of lung cancer mortality in male participants (hazard ratio (HR)=0.62, 95% confidence interval (CI)=0.46–0.82) and female participants (HR=0.41, 95% CI=0.29–0.57). Portable stove use is associated with reduced lung cancer mortality risk, highlighting a cost-effective intervention that could substantially benefit health in developing countries.
对家族史与肺癌风险之间关系的系统评价。
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