Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells.
Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells.
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DOI：
10.1155/2016/5170402
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发表时间：
2016
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Magee N;Zou A;Zhang Y
非酒精性脂肪性肝病（NAFLD）是西方国家最常见的慢性肝病类型，影响高达25%的普通人群，并成为成人和儿童的主要健康问题。NAFLD涵盖了没有大量饮酒的个体的脂肪肝疾病的整个谱，范围从非酒精性脂肪肝（NAFL）到非酒精性脂肪性肝炎（NASH）和肝硬化。NASH是代谢综合征和肝脏疾病的表现，存在脂肪变性、肝细胞损伤（气球样变）、炎症，并且在一些患者中，存在导致肝硬化的进行性纤维化。NASH的发病机制是一个复杂的过程，涉及肝实质细胞和非实质细胞之间的细胞相互作用以及肝脏中各种免疫细胞群之间的串扰。脂毒性似乎是通过氧化应激和内质网（ER）应激导致肝细胞损伤的主要驱动因素。本文综述了肝细胞和非实质细胞对NASH的贡献，评估了它们在开发新型治疗药物中的潜在应用。目前，NASH的药物治疗有限;因此，对NASH发病机制的了解增加与未来改善疾病干预有关。
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in both adults and children. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and cirrhosis. NASH is a manifestation of the metabolic syndrome and hepatic disorders with the presence of steatosis, hepatocyte injury (ballooning), inflammation, and, in some patients, progressive fibrosis leading to cirrhosis. The pathogenesis of NASH is a complex process and implicates cell interactions between liver parenchymal and nonparenchymal cells as well as crosstalk between various immune cell populations in liver. Lipotoxicity appears to be the central driver of hepatic cellular injury via oxidative stress and endoplasmic reticulum (ER) stress. This review focuses on the contributions of hepatocytes and nonparenchymal cells to NASH, assessing their potential applications to the development of novel therapeutic agents. Currently, there are limited pharmacological treatments for NASH; therefore, an increased understanding of NASH pathogenesis is pertinent to improve disease interventions in the future.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
29.4
作者：
Betrapally NS;Gillevet PM;Bajaj JS
通讯作者：
Bajaj JS
影响因子：
13.5
作者：
Csak, Timea;Ganz, Michal;Pespisa, Justin;Kodys, Karen;Dolganiuc, Angela;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
29.4
作者：
Chalasani N;Guo X;Loomba R;Goodarzi MO;Haritunians T;Kwon S;Cui J;Taylor KD;Wilson L;Cummings OW;Chen YD;Rotter JI;Nonalcoholic Steatohepatitis Clinical Research Network
通讯作者：
Nonalcoholic Steatohepatitis Clinical Research Network
非酒精性脂肪肝病的发病机理。
DOI：
10.1093/qjmed/hcp158
发表时间：
2010-02
期刊：
QJM : monthly journal of the Association of Physicians
影响因子：
--
作者：
Dowman JK;Tomlinson JW;Newsome PN
通讯作者：
Newsome PN