Functional brain connectivity and cognition: effects of adult age and task demands.

Functional brain connectivity and cognition: effects of adult age and task demands.
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DOI:
10.1016/j.neurobiolaging.2013.02.012
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发表时间:
2013-08
影响因子:
4.2
通讯作者:
Madden DJ
Madden DJ
中科院分区:
医学2区
文献类型:
--
作者:
Chou YH;Chen NK;Madden DJ

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先前的神经影像学研究已经证明,大脑区域之间的内在(静息态)功能连接(FC)模式随着个体认知表现的测量而变化。在这里,我们研究了内在 FC 和反应时间 (RT) 绩效衡量标准之间的关系,作为年龄组和任务要求的函数。我们从 21 名年轻人(19-29 岁)和 21 名健康老年人(60-87 岁)获得了经过过滤的、事件相关的功能磁共振成像 (fMRI) 数据和视觉搜索表现的 RT 测量。多个大脑区域的连接强度出现与年龄相关的下降,这与之前的发现一致。在躯体运动、眶额和皮质下网络的八对区域中,增加 FC 与更快的响应(较低的 RT)相关。相对于年轻人,老年人表现出这种 RT 连接关系的强度较低,并且显着但不相关的显示项目(颜色单一干扰项)对这种关系的破坏更大。内在 FC 和认知表现的协变中与年龄相关的差异随着任务需求的变化而变化。
Previous neuroimaging research has documented that patterns of intrinsic (resting-state) functional connectivity (FC) among brain regions covary with individual measures of cognitive performance. Here, we examined the relation between intrinsic FC and a reaction time (RT) measure of performance, as a function of both age group and task demands. We obtained filtered, event-related functional magnetic resonance imaging (fMRI) data, and RT measures of visual search performance, from 21 younger adults (19–29 years) and 21 healthy, older adults (60–87 years). Age-related decline occurred in the connectivity strength in multiple brain regions, consistent with previous findings. Among eight pairs of regions, across somatomotor, orbitofrontal, and subcortical networks, increasing FC was associated with faster responding (lower RT). Relative to younger adults, older adults exhibited a lower strength of this RT-connectivity relation and greater disruption of this relation by a salient but irrelevant display item (color singleton distractor). Age-related differences in the covariation of intrinsic FC and cognitive performance vary as a function of task demands.
额顶认知控制网络的年龄差异:对注意力分散的影响。
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