Affective response to physical activity as a deep phenotype in a non-randomized pilot study.
Affective response to physical activity as a deep phenotype in a non-randomized pilot study.
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DOI：
10.1038/s41598-022-09662-3
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发表时间：
2022-04-07
影响因子：
4.6
通讯作者：
Williams DM
中科院分区：
文献类型：
--
作者：
Lee HH;McGeary JE;Dunsiger S;Emerson JA;Bock B;McCaffery J;Dwyer K;Bryan AD;Williams DM
大规模的基因组研究开始确定体力活动(PA)的遗传预测因素。对于那些遗传倾向于低PA的人，行为干预可以针对调节低PA遗传易感性的可塑性因素(即中等表型)，以减轻遗传影响。在一项非随机化的运动促进试点研究中，我们测试了考察对PA的情感反应(PA期间的感受)作为遗传变异和PA坚持之间的中间表型的可行性。我们假设，从先前的系统综述中发现的三个单核苷酸多态(SNPs；FTO中的rs8044769和rs3751812；BDNF中的rs6265)将预测对PA的情感反应，并且对PA的情感反应将中介SNP-PA链接。45名健康、低活动量的成年人接受了为期12周的印刷PA推广计划。对PA的基线情感反应使用情感量表进行评估，这是一种情感效价的单项衡量标准。干预前后使用加速计评估中度至重度PA(MVPA)。我们在加权遗传评分中检查了这三个SNP。年龄、性别、体重指数、种族和邻里步行能力是潜在的协变量。对PA和MVPA的情感反应在随访时(在4-7天内每天几分钟)随着SNPs的变化而回归，控制了协变量。遗传分数每增加一个单位，平均感觉量表就高出0.14分，尽管在统计学上没有显著意义(p = 0.13)。在个体SNP中，具有额外的FTO rs8044769 C等位基因与情感量表的平均得分高0.53个单位相关(p = 0.015)，在应用校正的p值0.016后，这在统计学上是显著的。12周后，遗传评分或单个SNP不能预测MVPA，因此没有进行中介分析。初步的研究结果证明了中间表型方法的前景。
Large-scale genomic studies are beginning to identify genetic predictors of physical activity (PA). For those genetically predisposed to engage in low PA, a behavioral intervention may target a malleable factor that mediates genetic predisposition to low PA (i.e., intermediate phenotype) to mitigate the genetic influences. In a non-randomized exercise promotion pilot study, we test the feasibility of examining affective response to PA (how one feels during PA) as an intermediate phenotype between genetic variation and PA adherence. We hypothesized that three single nucleotide polymorphisms (SNPs; rs8044769 and rs3751812 in FTO; rs6265 in BDNF), identified from a prior systematic review, would be predictive of affective response to PA, and that affective response to PA would mediate the SNP-PA link. Forty five healthy, low-active adults received a 12-week print-based PA promotion program. Baseline affective response to PA was assessed using the Feeling Scale, a single-item measure of affective valence. Moderate to vigorous PA (MVPA) was assessed using accelerometers pre- and post-intervention. We examined the three SNPs in a weighted genetic score. Age, sex, body mass index, race, and neighborhood walkability were potential covariates. Affective response to PA and MVPA at follow-up (minutes/day over 4–7 days) were regressed on variation in SNPs, controlling for covariates. One unit increase in genetic score was associated with a 0.14 higher mean Feeling Scale, though was not statistically significant (p = 0.13). Among individual SNPs, having an additional FTO rs8044769 C allele was associated with a mean Feeling Scale score of 0.53 units higher (p = 0.015), which was statistically significant after applying the corrected p-value of 0.016. The genetic score or individual SNPs were not predictive of MVPA 12 weeks later, thereby mediation analyses were not performed. The preliminary findings demonstrate the promise of the intermediate phenotype approach.
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DOI：
10.1056/nejmsr1809937
发表时间：
2019-08-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
All of Us Research Program Investigators;Denny JC;Rutter JL;Goldstein DB;Philippakis A;Smoller JW;Jenkins G;Dishman E
通讯作者：
Dishman E
影响因子：
7.1
作者：
Franks, PW;Ravussin, E;Salbe, AD
通讯作者：
Salbe, AD
影响因子：
10.6
作者：
Dlugos, Andrea;Freitag, Christine;de Wit, Harriet
通讯作者：
de Wit, Harriet
DOI：
10.1249/01.mss.0000228941.17034.c1
发表时间：
2006-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Carlsson, Sofia;Andersson, Tomas;Ahlbom, Anders
通讯作者：
Ahlbom, Anders
影响因子：
2.6
作者：
Eriksson, M;Rasmussen, F;Tynelius, P
通讯作者：
Tynelius, P