Rhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice.
Rhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice.
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DOI：
10.1038/s41598-022-20376-4
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发表时间：
2022-11-23
影响因子：
4.6
通讯作者：
Liu, Suixin
中科院分区：
文献类型：
--
作者：
You, Baiyang;Cheng, Jing;Dun, Yaoshan;Ripley-Gonzalez, Jeffrey W.;Liu, Jie;Li, Dezhao;Fu, Siqian;Hong, Chuangxiong;Liu, Suixin
胰岛素抵抗（IR）对急性心脏应激下心肌损伤的减轻和恢复产生不利影响。我们以前证明，红景天提高小鼠心脏抗应激能力。因此，本研究旨在探讨红景天对力竭运动（EE）诱导的IR小鼠心肌损伤的预防作用。建立8周高脂饮食（HFD）IR小鼠模型。红景天通过车库给药。干预8周后，一半小鼠进行EE模拟急性心脏应激，测定心肌损伤;其余小鼠禁食后处死，评估代谢紊乱。我们发现EE引起的IR小鼠心肌损伤更严重，红景天预处理可减轻心肌损伤。此外，核因子红细胞2相关因子2（Nrf 2）相关的抗氧化系统被HFD损害，而线粒体动态融合和分裂被激活HFD作为生理保护补偿。红景天给药挽救了Nrf 2损伤，并进一步促进了线粒体融合和分裂。所有这些结果表明，红景天是一种潜在的治疗预防2型糖尿病和代谢综合征患者的心脏事件，和Nrf 2相关的抗氧化活性和线粒体动力学的建议机制。
Myocardial injury reduction and recovery under acute cardiac stress are adversely impacted by insulin resistance (IR). We previously demonstrated that Rhodiola improved cardiac anti-stress capacity in mice. Thus, this study focuses on the preventive efficacy of Rhodiola on exhaustive exercise (EE)-induced myocardial injury of IR mice. An 8-week high-fat diet (HFD) model of IR mice was established. Rhodiola was administrated by garaging. After the 8-week intervention, half of the mice performed EE to simulate acute cardiac stress, and determine myocardial injury; The remaining mice were sacrificed following fasting to assess metabolic disorder. We found myocardial injury induced by EE in IR mice was worse and was alleviated by Rhodiola pre-conditioning. Further, the nuclear factor erythroid 2-related factor 2 (Nrf2)-related antioxidant system was impaired by HFD, while mitochondrial dynamic fusion and fission were activated by HFD as a physiological protective compensation. The Rhodiola administration rescued Nrf2 impairment and further facilitated mitochondrial fusion and fission. All these results indicate that Rhodiola is a potential treatment for the prevention of cardiac events in type 2 diabetes mellitus and metabolic syndrome patients, and the Nrf2-related antioxidant activity and mitochondrial dynamics are the proposed mechanisms.
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DOI：
10.1016/0735-1097(93)90348-5
发表时间：
1993-03-15
影响因子：
24
作者：
GRANGER, CB;CALIFF, RM;TOPOL, EJ
通讯作者：
TOPOL, EJ
影响因子：
7.7
作者：
Shutt, Timothy;Geoffrion, Michele;McBride, Heidi M.
通讯作者：
McBride, Heidi M.
影响因子：
5.6
作者：
You B;Dun Y;Fu S;Qi D;Zhang W;Liu Y;Qiu L;Xie M;Liu S
通讯作者：
Liu S
DOI：
10.1080/13510002.2019.1658377
发表时间：
2019-12-01
期刊：
Redox report : communications in free radical research
影响因子：
--
作者：
Xu, Fengli;Xu, Jixiang;Deng, Yongqiong
通讯作者：
Deng, Yongqiong
影响因子：
5.1
作者：
Anzell AR;Maizy R;Przyklenk K;Sanderson TH
通讯作者：
Sanderson TH