Abnormal quantitative pupillary light responses following COVID-19.
Abnormal quantitative pupillary light responses following COVID-19.
复制标题
DOI：
10.1007/s10792-022-02275-9
复制
发表时间：
2022-09
影响因子：
1.6
通讯作者：
Malik RA
中科院分区：
文献类型：
--
作者：
Bitirgen G;Korkmaz C;Zamani A;Iyisoy MS;Kerimoglu H;Malik RA
描述2019冠状病毒病（COVID-19）受试者，尤其是长期COVID受试者瞳孔对光反射反应的变化。35名既往患有COVID-19的受试者和30名健康对照参与者参加了这项横断面比较研究。使用红外动态瞳孔测量系统（MonPack One; Metrovision，France）来量化瞳孔光响应。使用国家卫生和护理卓越研究所（NICE）长期COVID问卷来确定急性COVID-19后至少4周的持续症状。确诊急性COVID-19后的中位时间为4.0（2.0-5.0）个月。与健康对照组相比，COVID-19后受试者的瞳孔收缩潜伏期增加（P = 0.001），瞳孔收缩持续时间缩短（P = 0.039）。两组的初始瞳孔直径、瞳孔收缩幅度和速度以及瞳孔扩张的潜伏期、速度和持续时间均无显著性差异。25/35例（71%）受试者存在长时间COVID，与无长时间COVID的受试者相比，其瞳孔收缩持续时间缩短（P = 0.009）。NICE长期COVID问卷总分（ρ =-0.507; P = 0.002）和神经学评分（ρ =-0.412; P = 0.014）与瞳孔收缩的持续时间相关，总分与扩张的潜伏期相关（ρ =-0.352; P = 0.038）。动态瞳孔测量揭示收缩性瞳孔光反应的显著改变，表明COVID-19后副交感神经功能障碍。
To characterize alterations in pupillary light reflex responses in subjects following coronavirus disease 2019 (COVID-19), especially those with long-COVID. Thirty-five subjects with previous COVID-19 and 30 healthy control participants were enrolled in this cross-sectional comparative study. An infrared dynamic pupillometry system (MonPack One; Metrovision, France) was used to quantify pupillary light responses. The National Institute for Health and Care Excellence (NICE) long-COVID questionnaire was used to identify persisting symptoms at least 4 weeks after acute COVID-19. The median time after the diagnosis of acute COVID-19 was 4.0 (2.0–5.0) months. There was an increase in the latency of pupil contraction (P = 0.001) and a reduction in the duration of pupil contraction (P = 0.039) in post-COVID-19 subjects compared to healthy controls. No significant differences were observed in the initial pupil diameter, amplitude and velocity of pupil contraction or latency, velocity and duration of pupil dilation. Long-COVID was present in 25/35 (71%) subjects and their duration of pupil contraction was reduced compared to subjects without long-COVID (P = 0.009). The NICE long-COVID questionnaire total score (ρ = − 0.507; P = 0.002) and neurological score (ρ = − 0.412; P = 0.014) correlated with the duration of pupil contraction and the total score correlated with the latency of dilation (ρ = − 0.352; P = 0.038). Dynamic pupillometry reveals significant alterations in contractile pupillary light responses, indicative of parasympathetic dysfunction after COVID-19.
登录
查看更多内容
影响因子：
4.6
作者：
Bitirgen G;Turkmen K;Zengin N;Malik RA
通讯作者：
Malik RA
DOI：
10.1136/bjophthalmol-2021-319450
发表时间：
2022-12
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Bitirgen G;Korkmaz C;Zamani A;Ozkagnici A;Zengin N;Ponirakis G;Malik RA
通讯作者：
Malik RA
影响因子：
4.6
作者：
Barizien N;Le Guen M;Russel S;Touche P;Huang F;Vallée A
通讯作者：
Vallée A
影响因子：
7.4
作者：
Shiers S;Ray PR;Wangzhou A;Sankaranarayanan I;Tatsui CE;Rhines LD;Li Y;Uhelski ML;Dougherty PM;Price TJ
通讯作者：
Price TJ
影响因子：
3.6
作者：
Charfeddine S;Ibn Hadj Amor H;Jdidi J;Torjmen S;Kraiem S;Hammami R;Bahloul A;Kallel N;Moussa N;Touil I;Ghrab A;Elghoul J;Meddeb Z;Thabet Y;Kammoun S;Bouslama K;Milouchi S;Abdessalem S;Abid L
通讯作者：
Abid L