Vitamin D deficiency is correlated with poor outcomes in patients with luminal-type breast cancer.
Vitamin D deficiency is correlated with poor outcomes in patients with luminal-type breast cancer.
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DOI：
10.1245/s10434-010-1465-6
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发表时间：
2011-07
影响因子：
3.7
通讯作者：
Ahn SH
中科院分区：
文献类型：
--
作者：
Kim HJ;Lee YM;Ko BS;Lee JW;Yu JH;Son BH;Gong GY;Kim SB;Ahn SH
维生素D缺乏可能是乳腺癌患者手术前预后不良的指标。我们调查了血清维生素D浓度和乳腺癌预后之间的关系，根据内在的癌症亚型。从2006年6月至12月，对310名在韩国牙山医疗中心接受治疗的韩国乳腺癌妇女进行了血清25-OHD测定。临床病理资料进行了检查，以确定血清25-OHD的预后影响。雌激素受体（ER），孕激素受体（PR）和表皮生长因子受体2（Her 2）的表达进行了测量，使用组织芯片。将患者分为管腔A型、管腔B型、Her 2富集型或基底样型乳腺癌亚型。患者平均年龄为48.7岁，平均血清25-OHD浓度为31.4 ± 16.1 ng/ml。25-OHD水平不足（< 20 ng/ml）75例（24.2%），不足（20-29 ng/ml）95例（30.6%），充足（30-150 ng/ml）140例（45.2%）。与维生素D水平充足的妇女相比，25-OHD水平不足的妇女复发风险增加（P = 0.002）。25-OHD浓度与管腔A（P = 0.012）和管腔B亚型（P = 0.023）癌症患者的预后呈负相关，但与Her 2/neu富集（P = 0.245）或三阴性（P = 0.879）癌症亚型患者的预后无关。在校正年龄、肿瘤大小、淋巴结状态和雌激素受体状态后，这种相关性仍然有效（风险比= 3.97; 95%置信区间= 1.77-9.61）。维生素D缺乏可能与管腔型乳腺癌患者的预后不良有关。
Vitamin D deficiency may be an indicator of poor prognosis in patients with breast cancer before surgery. We investigated the association between serum vitamin D concentration and breast cancer prognosis according to intrinsic cancer subtypes. From June to December 2006, serum 25-OHD was measured in 310 Korean women with breast cancer who were treated at the Asan Medical Center, Korea. Clinicopathologic data were examined to determine the prognostic effects of serum 25-OHD. Expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (Her2) were measured using tissue microarrays. Patients were classified with luminal A, luminal B, Her2-enriched, or basal-like subtypes of breast cancer. Mean patient age was 48.7 years, and mean serum 25-OHD concentration was 31.4 ± 16.1 ng/ml. The 25-OHD levels were deficient (< 20 ng/ml) in 75 patients (24.2%), insufficient (20–29 ng/ml) in 95 (30.6%), and sufficient (30–150 ng/ml) in 140 (45.2%). Women with deficient 25-OHD levels were at increased risk of recurrence compared with those with sufficient vitamin D levels (P = 0.002). The 25-OHD concentration was inversely associated with prognosis of patients with cancer of the luminal A (P = 0.012) and luminal B subtypes (P = 0.023), but not with the prognosis of patients with Her2/neu-enriched (P = 0.245) or triple-negative (P = 0.879) cancer subtypes. This association remained valid after adjustment for age, tumor size, nodal status, and estrogen receptor status (hazards ratio = 3.97; 95% confidence interval = 1.77–9.61). Vitamin D deficiency may be associated with poor outcomes in patients with luminal-type breast cancer.
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影响因子：
2.3
作者：
Knight, Julia A.;Wong, Jody;Vieth, Reinhold
通讯作者：
Vieth, Reinhold
影响因子：
6.9
作者：
Ho-Pham, Lan T.;Lai, Thai Q.;Nguyen, Tuan V.
通讯作者：
Nguyen, Tuan V.
影响因子：
2.7
作者：
Narvaez, CJ;Zinser, G;Welsh, J
通讯作者：
Welsh, J
影响因子：
4.8
作者：
Narvaez, CJ;Welsh, J
通讯作者：
Welsh, J
DOI：
10.2215/cjn.01350308
发表时间：
2008-09-01
影响因子：
9.8
作者：
Holick, Michael F.
通讯作者：
Holick, Michael F.