Community-engaged ancient DNA project reveals diverse origins of 18th-century African descendants in Charleston, South Carolina.
Community-engaged ancient DNA project reveals diverse origins of 18th-century African descendants in Charleston, South Carolina.
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DOI：
10.1073/pnas.2201620120
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发表时间：
2023-01-17
影响因子：
11.1
通讯作者：
Schurr, Theodore G.
中科院分区：
文献类型：
--
作者：
Fleskes, Raquel E.;Cabana, Graciela S.;Gilmore, Joanna K.;Juarez, Chelsey;Karcher, Emilee;Oubre, La'Sheia;Mishoe, Grant;Ofunniyin, Ade A.;Schurr, Theodore G.
通过安森街非洲墓地项目，我们利用生物考古学和基因组方法调查了来自南卡罗来纳州查尔斯顿的 36 名 18 世纪个体的生活。我们报告了 18 名个体的低覆盖率基因组数据，这些数据揭示了整个西非祖先联系的多样性，其中包括一名与西非富拉尼人有基因组关系的个体。总体而言，这项研究描述了来自北美非洲人后裔的最大数量的古代基因组，大大增加了我们对非洲多样性和美洲殖民地历史的了解。这项研究进一步展示了如何与利益相关者群体密切合作进行古代 DNA 研究，这是建立古基因组学领域伦理框架的关键一步。在这项研究中，我们展示了社区参与的古代 DNA 研究的结果，该研究是在南卡罗来纳州港口城市查尔斯顿出土了 36 具可追溯至 18 世纪末的非洲人后裔遗骸后发起的。查尔斯顿古拉协会与其他查尔斯顿社区成员一起，对这些被认为是奴隶的祖先发起了一项基因组合作研究，以期了解他们的历史。我们生成了 18 个低覆盖率基因组和 31 个单亲单倍型来评估它们的遗传起源和相互关系。我们的结果表明，他们主要具有西非和中西部非洲的基因组血统，其中一个个体表现出与美洲人群的某种基因组联系。大多数人被评估为遗传男性，并且其中没有发现常染色体亲属。总体而言，这项研究扩大了我们对美国南部非洲人后裔殖民历史的理解。
Through the Anson Street African Burial Ground Project, we have investigated the lives of thirty-six 18th-century individuals from Charleston, South Carolina, using bioarchaeological and genomic methods. We report low coverage genomic data from 18 individuals that reveal a diversity of ancestral connections across western Africa, including one individual with genomic affiliations with Fulani peoples of West Africa. Overall, this study describes the largest number of ancient genomes from African-descended persons in North America, substantially increasing our understanding of African diversity and history in colonial America. This study further demonstrates how ancient DNA research can be conducted in close collaboration with stakeholder communities, which is a critical step in building an ethical framework for the field of paleogenomics. In this study, we present the results of community-engaged ancient DNA research initiated after the remains of 36 African-descended individuals dating to the late 18th century were unearthed in the port city of Charleston, South Carolina. The Gullah Society of Charleston, along with other Charleston community members, initiated a collaborative genomic study of these ancestors of presumed enslaved status, in an effort to visibilize their histories. We generated 18 low-coverage genomes and 31 uniparental haplotypes to assess their genetic origins and interrelatedness. Our results indicate that they have predominantly West and West-Central African genomic ancestry, with one individual exhibiting some genomic affiliation with populations in the Americas. Most were assessed as genetic males, and no autosomal kin were identified among them. Overall, this study expands our understanding of the colonial histories of African descendant populations in the US South.
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影响因子：
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影响因子：
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