Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983.
Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983.
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1915 年至 1983 年间从流行病和大流行病中分离出的 A 群脑膜炎奈瑟菌的克隆群体结构。
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Achtman
中科院分区：
文献类型：
--
作者：
T. Olyhoek;B. Crowe;M. Achtman
已经建立了一个细菌菌株收集库，其中包括从1960年以来发生的23次流行或暴发以及早期流行和许多非流行情况中分离的423株脑膜炎奈瑟菌血清组A。结合淀粉凝胶电泳的7种细胞质酶和十二烷基硫酸钠-聚丙烯酰胺凝胶电泳的两个外膜蛋白，以解决这些细菌的克隆种群结构。聚类分析的基础上，50电泳类型分配给21个克隆。这些克隆被分成四个不同的血清群A亚群，所有这些亚群都是从1983年的病例中分离出来的。大多数流行病或暴发的特点是与一个单一的或占优势的克隆，虽然有些流行病显然是混合病因和其他人产生罕见的分离株属于其他克隆。自1915年以来，七个主要的克隆被认为引起了一系列的流行病。其中至少有两组可以被认为是分别在1967年和1973年首次发现的相互排斥的大流行病。结果定义了一个新的分型方案，可用于全面描述以前和未来的流行病。随附菌株及其流行病学数据列表。
A bacterial strain collection has been established consisting of 423 strains of Neisseria meningitidis serogroup A isolated from 23 epidemics or outbreaks that have occurred since 1960 as well as from earlier epidemics and from numerous nonepidemic situations. A combination of starch gel electrophoresis of seven cytoplasmic enzymes and sodium dodecyl sulfate-polyacrylamide gel electrophoresis of two outer membrane proteins was used to resolve the clonal population structure of these bacteria. Fifty electrophoretic types were assigned to 21 clones on the basis of a cluster analysis. The clones were separated into four distinct serogroup A subgroups, all of which were isolated from cases as recently as 1983. Most epidemics or outbreaks were characterized by their association with a single or predominant clone, although some epidemics were apparently of mixed etiology and others yielded rare isolates belonging to other clones. Seven predominant clones were recognized that have caused sets of epidemics since 1915. At least two of these sets can be considered to represent mutually exclusive pandemics first detected in 1967 and 1973, respectively. The results define a new typing scheme, which can be used for a comprehensive description of former and future epidemics. A list of strains and their epidemiologic data is appended.
流行性脑膜炎球菌病：假设免疫流行病学模型的综合。
DOI：
10.1093/clinids/4.1.159
发表时间：
1982
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Griffiss,JM
通讯作者：
Griffiss,JM
用于研究 b 型流感嗜血杆菌菌株引起的侵袭性疾病的群体遗传框架。
DOI：
10.1073/pnas.82.15.5078
发表时间：
1985
影响因子：
11.1
作者：
Musser,JM;Granoff,DM;Pattison,PE;Selander,RK
通讯作者：
Selander,RK