Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities.
Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities.
复制标题
正常血脂吸烟男性餐后高密度脂蛋白胆固醇和载脂蛋白 A-I 和 E 降低：与脂质转移蛋白和 LCAT 活性的关系。
DOI：
--
复制
发表时间：
1998
影响因子：
6.5
通讯作者：
M. Taskinen
中科院分区：
文献类型：
--
作者：
N. Mero;A. Tol;L. Scheek;T. Gent;Christine Labeur;Maryvonne Rosseneu;M. Taskinen
我们之前曾报道，与非吸烟者相比，血脂正常的吸烟者由于富含甘油三酯的脂蛋白 (TRL) 载脂蛋白 B-48、甘油三酯 (TG) 和视黄酯对混合膳食的反应增加而出现脂质不耐受。为了调查餐后高密度脂蛋白 (HDL)、载脂蛋白 A-I (apoA-I)、载脂蛋白 A-II (apoA-II) 和载脂蛋白 E (apoE) 浓度或脂质转移蛋白活性是否受到吸烟的影响，我们调查了 12 名男性吸烟者和 12 名非吸烟者，他们的空腹脂蛋白谱、BMI 和年龄具有相似性。通过密度梯度超速离心分离禁食过夜和餐后获得的血浆样品。吸烟者的餐后 apoA-I、脂蛋白 AI 颗粒 (LpA-I)、HDL-胆固醇和 HDL apoE 浓度降低，但在对照组中保持不变。与此同时，吸烟者 TRL 组分中的胆固醇和 apoE 浓度显着增加。空腹卵磷脂：胆固醇酰基转移酶（LCAT）和磷脂转移蛋白（PLTP）活性水平以及酯化率（EST）和磷脂转移率在各组之间具有可比性。吸烟者的胆固醇酯转移蛋白（CETP）活性水平较低。与对照组相比，吸烟者餐后 EST 增加，但 CETP 和 PLTP 活性下降。我们的结论是，即使是健康、血脂正常的吸烟者也会改变餐后高密度脂蛋白（HDL）胆固醇和载脂蛋白组成，以及脂质转移蛋白活性。胆固醇和 apoE 从 HDL 转移到富含甘油三酯的脂蛋白 (TRL) 部分，加上消化性脂血症期间血浆 apoA-I 和 LpA-I 浓度降低，可能表明胆固醇反向转运受损。餐后 TRL 的增加和 HDL 的降低都可能促进吸烟者的动脉粥样硬化形成。
We have previously reported that normolipidemic smokers are lipid intolerant due to increased responses of triglyceride-rich lipoproteins (TRL) apolipoprotein B-48, triglyceride (TG), and retinyl esters to a mixed meal compared to non-smokers. To investigate whether postprandial high density lipoprotein (HDL), apolipoprotein A-I (apoA-I), apolipoprotein A-II (apoA-II), and apolipoprotein E (apoE) concentrations or lipid transfer protein activities are affected by cigarette smoking, we investigated 12 male smokers and 12 non-smokers with comparable fasting lipoprotein profile, BMI, and age. Plasma samples obtained after an overnight fast and postprandially were separated by density gradient ultracentrifugation. Postprandial apoA-I, lipoprotein AI-particles (LpA-I), HDL-cholesterol, and HDL apoE concentrations decreased in smokers, but remained unchanged in controls. Concomitantly, cholesterol and apoE concentrations increased significantly in TRL fractions in smokers. Fasting lecithin:cholesterol acyltransferase (LCAT) and phospholipid transfer protein (PLTP) activity levels, as well as esterification rates (EST) and phospholipid transfer rates were comparable between the groups. Cholesteryl ester transfer protein (CETP) activity levels were lower in the smokers. Postprandially EST increased, but CETP and PLTP activities deceased in smokers as compared to controls. We conclude, that even healthy, normolipidemic smokers have altered postprandial high density lipoprotein (HDL) cholesterol and apolipoprotein composition, as well as lipid transfer protein activities. The shift of cholesterol and apoE from HDL to the triglyceride-rich lipoprotein (TRL) fraction, together with decreased plasma apoA-I and LpA-I concentrations during alimentary lipemia may indicate impaired reverse cholesterol transport. Both the postprandial increase in TRL and the lowering of HDL may promote atherogenesis in smokers.
登录
查看更多内容
DOI：
10.1016/0005-2760(95)00091-p
发表时间：
1995-08-24
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM
影响因子：
--
作者：
ALBERS, JJ;WOLFBAUER, G;TU, AY
通讯作者：
TU, AY
DOI：
10.1056/nejm198811173192005
发表时间：
1988-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
N. Benowitz
通讯作者：
N. Benowitz
DOI：
10.1016/0026-0495(86)90045-4
发表时间：
1986
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
deParscau,L;Fielding,CJ
通讯作者：
Fielding,CJ
DOI：
10.1161/01.atv.16.12.1430
发表时间：
1996-12-01
影响因子：
8.7
作者：
Foger, B;Ritsch, A;Patsch, JR
通讯作者：
Patsch, JR
ApoE 对于富含甘油三酯的大脂蛋白与 LDL 受体的结合是必要且充分的；
影响因子：
6.5
作者：
Bradley,WA;Gianturco,SH
通讯作者：
Gianturco,SH