Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection.
Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection.
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DOI：
10.1186/s12941-018-0282-9
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发表时间：
2018-07-09
影响因子：
5.7
通讯作者：
Ohga S
中科院分区：
文献类型：
--
作者：
Okuzono S;Ishimura M;Kanno S;Sonoda M;Kaku N;Motomura Y;Nishio H;Oba U;Hanada M;Fukushi JI;Urata M;Kang D;Takada H;Ohga S
化脓性链球菌是一种少见的暴发性紫癜致病菌，其致病机制尚不清楚。化脓性暴发性紫癜由于病例少而仍不清楚。本文报告1例儿童S.化脓性-暴发性紫癜，并对该病进行文献复习。1例3岁男童24 h内出现跛行、嗜睡、肢端坏疽。诊断为S.制备化脓性暴发性紫癜咽部及外周血标本进行细菌分离。强化治疗导致左远端跖骨截肢的生存和正常发育。分离的M12不携带csrS/R或rgg突变。排除血栓形成倾向或免疫缺陷。既往报道的病例（9例儿童和3例老年人）中，化脓性暴发性紫癜以休克和凝血障碍开始。5例患者年龄< 8岁，无基础疾病，均存活。一名最年轻的患者和两名免疫功能低下的患者死亡。化脓性链球菌-急性传染性暴发性紫癜是一种独特的罕见形式的侵略性气体感染。
Streptococcus pyogenes is an uncommon pathogen of purpura fulminans, and the pathogenesis of S. pyogenes-purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of S. pyogenes-purpura fulminans with literature review of the disease. A 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of S. pyogenes-purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of csrS/R or rgg. Thrombophilia or immunodeficiency was excluded. Twelve-reported cases (9 pediatric and 3 elderly) of S. pyogenes-purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died. Streptococcus pyogenes-acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections.
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影响因子：
3.6
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通讯作者：
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