Generation Scotland: Donor DNA Databank; A control DNA resource.
Generation Scotland: Donor DNA Databank; A control DNA resource.
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DOI：
10.1186/1471-2350-11-166
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发表时间：
2010-11-23
影响因子：
--
通讯作者：
Porteous DJ
中科院分区：
文献类型：
--
作者：
Kerr SM;Liewald DC;Campbell A;Taylor K;Wild SH;Newby D;Turner M;Porteous DJ
许多具有公共卫生重要性的医学疾病是由多种遗传、环境和生活方式因素引起的复杂疾病。最近的技术进步使人们有可能分析易患复杂疾病的遗传变异。这些变异的可靠检测需要在足够大量的病例和对照中进行全基因组关联研究。这一方法常常因难以收集适当的对照样品而受阻。苏格兰一代：供体DNA数据库（GS：3D）旨在通过提供可用于研究的对照DNA和血浆样本资源来帮助解决这一问题。GS：3D参与者是从苏格兰全国输血服务中心（SNBTS）诊所的志愿献血者中招募的。所有受试者均书面同意GS：3D从其正常献血中采集备用血液。参与者还通过填写一份简短的问卷提供了人口统计数据。收集了5000多套完整的样本、数据和同意书。提取DNA和血浆并储存。数据和样本与其原始SNBTS标识符编号无关。血浆、DNA和人口统计数据可用于研究。从资源分析中获得的新数据将反馈到GS：3D，并将酌情提供给其他研究人员。招募献血者是一种有效和具有成本效益的方法，可以收集数千份对照样本。由于收集的样本量很大，因此可以根据年龄范围、性别、种族或地理来源选择对照样本的子集。GS：3D资源应该减少研究者的时间和费用，否则他们必须招募自己的对照。
Many medical disorders of public health importance are complex diseases caused by multiple genetic, environmental and lifestyle factors. Recent technological advances have made it possible to analyse the genetic variants that predispose to complex diseases. Reliable detection of these variants requires genome-wide association studies in sufficiently large numbers of cases and controls. This approach is often hampered by difficulties in collecting appropriate control samples. The Generation Scotland: Donor DNA Databank (GS:3D) aims to help solve this problem by providing a resource of control DNA and plasma samples accessible for research. GS:3D participants were recruited from volunteer blood donors attending Scottish National Blood Transfusion Service (SNBTS) clinics across Scotland. All participants gave full written consent for GS:3D to take spare blood from their normal donation. Participants also supplied demographic data by completing a short questionnaire. Over five thousand complete sets of samples, data and consent forms were collected. DNA and plasma were extracted and stored. The data and samples were unlinked from their original SNBTS identifier number. The plasma, DNA and demographic data are available for research. New data obtained from analysis of the resource will be fed back to GS:3D and will be made available to other researchers as appropriate. Recruitment of blood donors is an efficient and cost-effective way of collecting thousands of control samples. Because the collection is large, subsets of controls can be selected, based on age range, gender, and ethnic or geographic origin. The GS:3D resource should reduce time and expense for investigators who would otherwise have had to recruit their own controls.
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