Biomimetic Nanofibrous 3D Materials for Craniofacial Bone Tissue Engineering.
Biomimetic Nanofibrous 3D Materials for Craniofacial Bone Tissue Engineering.
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DOI：
10.1021/acsabm.0c00946
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发表时间：
2020-10-19
影响因子：
4.7
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Miszuk JM;Hu J;Sun H
由于组织再生所需的复杂特性，尤其是在颅面部，使用基于生物材料的策略修复大型骨缺损一直是一个巨大的挑战。以恢复功能为目标的组织工程策略在材料选择、合成技术、生物活性因子释放的选择等方面都面临着挑战。仿生纳米纤维支架能够模拟天然骨细胞外基质的形态和化学结构，促进内源性骨再生，是一种极具吸引力的组织工程载体。到目前为止，已经发现了几种产生仿生核因子支架的技术，每一种技术都有几个优点和缺点。本聚焦重点介绍了两种比较流行的仿生核磁共振支架合成技术：静电纺丝和热诱导相分离(TIPS)，涵盖了每种技术的发展，并讨论了每种制造方法的最新创新。
Repair of large bone defects using biomaterials-based strategies has been a significant challenge due to the complex characteristics required for tissue regeneration, especially in the craniofacial region. Tissue engineering strategies aimed at restoration of function face challenges in material selection, synthesis technique, and choice of bioactive factor release in combination with all aforementioned facets. Biomimetic nanofibrous (NF) scaffolds are attractive vehicles for tissue engineering due to their ability to promote endogenous bone regeneration by mimicking the shape and chemistry of natural bone extracellular matrix (ECM). To date, several techniques for generation of biomimetic NF scaffolds have been discovered, each possessing several advantages and drawbacks. This spotlight highlights two of the more popular techniques for biomimetic NF scaffold synthesis: electrospinning and thermally-induced phase separation (TIPS), covering development from inception in each technique as well as discussing the most recent innovations in each fabrication method.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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10.1016/j.jconrel.2010.05.035
发表时间：
2010-09-15
期刊：
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影响因子：
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