C-reactive protein and telomerase reverse transcriptase (TERT) associate with chronic disease markers in a sample from low-income neighborhoods in Detroit, Michigan.
C-reactive protein and telomerase reverse transcriptase (TERT) associate with chronic disease markers in a sample from low-income neighborhoods in Detroit, Michigan.
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DOI：
10.1016/j.smhs.2022.07.002
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发表时间：
2022-12
影响因子：
--
通讯作者：
Pearson, Amber L.
中科院分区：
文献类型：
--
作者：
Ferguson, David P.;Leszczynski, Eric C.;Horton, Teresa H.;Pfeiffer, Karin A.;Gardiner, Joseph;Pearson, Amber L.
与社会经济地位较高的社区相比，经济贫困的内城的种族和少数民族患慢性病的比例很高。然而，这些经济贫困人群在与慢性疾病风险相关的生物标志物方面研究不足，这些生物标志物包括C反应蛋白（CRP），端粒酶逆转录酶（TERT）和糖化血红蛋白（A1 C）。我们研究了密歇根州底特律市两个低收入，主要是非洲裔美国人（AA）社区的CRP和TERT与慢性疾病指标（体重指数[BMI]和A1 C）之间的关系。69名成年人（43名女性，26名男性，平均年龄46岁[y]，标准差[SD] = 15.9）完成了健康调查、人体测量和手指针刺血液检查。使用A1 CNow试纸测量A1 C，使用酶联免疫吸附测定（ELISA）测量从干血斑提取的样本的CRP和TERT水平。我们按BMI类别检查了CRP（平均值= 4.9，SD = 3.1）、TERT（平均值= 32.5，SD = 15.1）和A1 C（平均值= 5.4，SD = 1.0）。我们拟合了限制性最大似然回归模型，以评估CRP，TERT，BMI和A1 C之间的关联，在调整人口统计学和纳入随机效应的邻居。在这份主要为AA的样本（91%，63/69）中，68%的样本的CRP水平（AA的平均值= 4.8 mg/L，SD = 3.0;所有其他样本的平均值= 6.4 mg/L，SD = 3.9）表明慢性炎症（CRP> 3 mg/L）。BMI与CRP（p = 0.004）和TERT（p = 0.026）显著相关。TERT水平表明超重与染色体重塑的标志物有关，提示慢性疾病。CRP也有类似的趋势，超重的人有更高的炎症和慢性疾病的风险。我们的研究结果保证了进一步探索可能影响CRP和TERT的其他因素。此外，在一个种族和/或经济上更加多样化，但比例仍然很高的少数民族样本中检查人口，将填补这一研究不足领域的知识空白。
Racial and ethnic minorities in economically deprived inner cities experience high rates of chronic diseases compared to neighborhoods with higher socioeconomic status (SES). However, these economically deprived populations are understudied in terms of biomarkers associated with chronic disease risk which include C-reactive protein (CRP), telomerase reverse transcriptase (TERT), and glycosylated hemoglobin (A1C). We examined relationships between CRP and TERT and chronic disease indicators (body mass index [BMI] and A1C) in two low-income, predominantly African American (AA) neighborhoods in Detroit, Michigan. Sixty-nine adults (43 females, 26 males, mean age 46 years [y], standard deviation [SD] = 15.9) completed a health survey, anthropometry, and finger stick blood tests. A1C was measured using A1CNow test strips, and CRP and TERT levels were measured using enzyme-linked immunosorbent assay (ELISA) with samples extracted from dried blood spots. We examined CRP (mean = 4.9, SD = 3.1), TERT (mean = 32.5, SD = 15.1), and A1C (mean = 5.4, SD = 1.0) by BMI category. We fitted restricted maximum likelihood regression models to evaluate associations between CRP, TERT, BMI, and A1C, after adjustment for demographics and inclusion of a random effect for the neighborhood. In this predominantly AA sample (91%, 63/69), 68% had levels of CRP (means = 4.8 mg/L, SD = 3.0 for AAs; 6.4 mg/L, SD = 3.9 for all others) indicative of chronic inflammation (CRP greater than 3 mg/L). BMI was significantly associated with CRP (p = 0.004) and TERT (p = 0.026). TERT levels indicate that being overweight is associated with markers of chromosome remodeling, suggestive of chronic disease. CRP followed a similar trend with overweight individuals having higher inflammation and risk of chronic disease. Our findings warrant further exploration of additional factors that may influence CRP and TERT. Furthermore, examining populations in a more ethnically and/or economically diverse, yet still high proportion minority, sample will fill a knowledge gap in this understudied field.
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