Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method.
Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method.
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DOI：
10.1038/oby.2011.302
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发表时间：
2012-02
期刊：
影响因子：
6.9
通讯作者：
Gao, Xin
中科院分区：
文献类型：
--
作者：
Xia, Ming-Feng;Yan, Hong-Mei;He, Wan-Yuan;Li, Xiao-Ming;Li, Chao-Lun;Yao, Xiu-Zhong;Li, Ruo-Kun;Zeng, Meng-Su;Gao, Xin
肝脏脂肪含量的准确测量对于研究肝脏脂肪变性在多种代谢紊乱的病理生理学中的作用至关重要。没有一种传统的成像方法可以准确地量化肝脏脂肪含量。[1H]-由于实际和技术问题，磁共振波谱(MRS)在大规模研究中受到限制。以前的计算机辅助超声定量肝脏脂肪含量的尝试方法各不相同，不同超声机测量的超声定量参数很难进行比较。本研究以[1H]-MRS为金标准，建立并验证了一种基于标准化超声定量参数组合的简便、可推广的肝脏脂肪含量定量评估方法。共有127名参与者同时接受了超声检查和[1H]-MRS检查。用计算机程序从普通超声图像中获得超声肝/肾回声强度比(H/R)和肝脏回声强度衰减率(HA)。在分析之前，使用模拟组织的体模对这两个参数进行标准化。[1H]-MRS显示标准化超声H/R和HA与肝脏脂肪含量呈正相关(r=0.884，P<0.001和r=0.711，P<0.001)。线性回归分析显示，超声H/R可适度预测肝脏脂肪含量(校正解释方差78.0%，P<；0.001)。超声透明质酸的加入使调整后的解释方差略有改善，达到79.8%。不同超声仪和操作人员估计的肝脏脂肪含量差异相当大。因此，计算机辅助超声是一种估算肝脏脂肪含量的有效方法，在超声定量参数标准化后可广泛应用。
Accurate measures of liver fat content are essential for investigating the role of hepatic steatosis in the pathophysiology of multiple metabolic disorders. No traditional imaging methods can accurately quantify liver fat content. [1H]-magnetic resonance spectroscopy (MRS) is restricted in large-scale studies because of the practical and technological issues. Previous attempts on computer-aided ultrasound quantification of liver fat content varied in method, and the ultrasound quantitative parameters measured from different ultrasound machines were hardly comparable. We aimed to establish and validate a simple and propagable method for quantitative assessment of liver fat content based on the combination of standardized ultrasound quantitative parameters, using [1H]-MRS as gold standard. Totally 127 participants were examined with both ultrasonography (US) and [1H]-MRS. Ultrasound hepatic/renal echo-intensity ratio (H/R) and ultrasound hepatic echo-intensity attenuation rate (HA) were obtained from ordinary ultrasound images using computer program. Both parameters were standardized using a tissue-mimicking phantom before analysis. Standardized ultrasound H/R and HA were positively correlated with the liver fat content by [1H]-MRS (r = 0.884, P < 0.001 and r = 0.711, P < 0.001, respectively). Linear regression analysis showed ultrasound H/R could modestly predict the amount of liver fat (adjusted explained variance 78.0%, P < 0.001). The addition of ultrasound HA slightly improved the adjusted explained variance to 79.8%. Difference of estimated liver fat contents between different ultrasound machines and operators was reasonably well. Thus, computer-aided US is a valid method to estimate liver fat content and can be applied extensively after standardization of ultrasound quantitative parameters.
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DOI：
10.1109/tuffc.2008.831
发表时间：
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影响因子：
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