ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.
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DOI：
10.1016/j.bbrc.2009.03.014
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发表时间：
2009-05-01
影响因子：
3.1
通讯作者：
Sjoholm, Kajsa
中科院分区：
文献类型：
--
作者：
Carlsson, Lena M. S.;Jacobson, Peter;Walley, Andrew;Froguel, Philippe;Sjostrom, Lars;Svensson, Per-Arne;Sjoholm, Kajsa
人脂肪组织是脂肪素β B（INHB B）的主要表达部位，INHB B同源二聚化形成新的脂肪因子激活素B。我们的目的是确定激活素B局部作用所需的分子是否在脂肪组织中表达。微阵列分析表明，脂肪组织表达激活素I型和II型受体，激活素受体样激酶7（ALK 7）的表达是脂肪组织特异性的。在SOS同胞配对研究中，肥胖不一致的同胞中，瘦型（n = 90）受试者的脂肪组织ALK 7表达高于肥胖（n = 90）受试者（p = 4 × 10−31）。脂肪组织ALK 7表达与体脂、碳水化合物代谢和脂质的几个指标相关。此外，ALK 7和INHBB表达相关，但仅在瘦受试者和正常葡萄糖耐量受试者中。我们的结论是激活素B可能在脂肪组织中具有局部作用，从而影响肥胖及其合并症。
Human adipose tissue is a major site of expression of inhibin beta B (INHBB) which homodimerizes to form the novel adipokine activin B. Our aim was to determine if molecules needed for a local action of activin B are expressed in adipose tissue. Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 (ALK7) was adipose tissue specific. In obesity discordant siblings from the SOS Sib Pair study, adipose tissue ALK7 expression was higher in lean (n = 90) compared to obese (n = 90) subjects (p = 4 × 10−31). Adipose tissue ALK7 expression correlated with several measures of body fat, carbohydrate metabolism and lipids. In addition, ALK7 and INHBB expression correlated but only in lean subjects and in subjects with normal glucose tolerance. We conclude that activin B may have local effects in adipose tissue and thereby influence obesity and its comorbidities.
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影响因子：
4.8
作者：
Schneyer, A;Schoen, A;Sidis, Y
通讯作者：
Sidis, Y
DOI：
10.1016/j.bbrc.2006.04.030
发表时间：
2006-06-16
影响因子：
3.1
作者：
Sjoholm, Kajsa;Palming, Jenny;Carlsson, Lena M. S.
通讯作者：
Carlsson, Lena M. S.
影响因子：
4.1
作者：
Tsuchida, K;Nakatani, M;Sugino, H
通讯作者：
Sugino, H
影响因子：
0.7
作者：
Kogame, Masahiro;Matsuo, Shinji;Sugino, Hiromu
通讯作者：
Sugino, Hiromu
DOI：
10.1073/pnas.0810772105
发表时间：
2008-12-30
影响因子：
11.1
作者：
Lage, Kasper;Hansen, Niclas Tue;Brunak, Soren
通讯作者：
Brunak, Soren