Dual skin testing with Mycobacterium avium sensitin and purified protein derivative: an open study of patients with M. avium complex infection or tuberculosis.

Dual skin testing with Mycobacterium avium sensitin and purified protein derivative: an open study of patients with M. avium complex infection or tuberculosis.
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使用鸟分枝杆菌敏感素和纯化蛋白衍生物进行双重皮肤测试:对鸟分枝杆菌复合感染或结核病患者的开放研究。

DOI:
10.1093/clinids/19.1.15
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发表时间:
1994
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
Barber,TW
Barber,TW
中科院分区:
--
文献类型:
--
作者:
vonReyn,CF;Green,PA;McCormick,D;Huitt,GA;Marsh,BJ;Magnusson,M;Barber,TW

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在一项非盲研究中,对22例培养证实的鸟分枝杆菌复合群(MAC)感染和20例培养证实的结核分枝杆菌感染的患者进行了双重分枝杆菌皮肤试验的敏感性和特异性评估。用0.1 mL ofM进行皮内皮肤试验。aviumsensitin、0.1 mL PPD(纯化蛋白衍生物)和两种对照抗原(腮腺炎和念珠菌)。所有M.结核感染对皮试有反应,PPD组反应面积为19.7 ± 1.4mm,M组为10.3 ± 1.5mm。给予阿维敏汀。4例MAC患者无反应性;其余18例患者的平均反应为15.2 ± 1.4 mm to M。与PPD的距离为4.3 ± 1.3 mm。皮肤试验定义为M。鸟优势型或PPD(M.如果对给定物种的最小反应尺寸为1.5mm,并且对给定物种的反应比对异源物种的反应大1.3mm,则为结核病)-显性。20例M患者中有18例(90%)出现主要皮肤试验反应。18例无反应性MAC患者中15例(83%)。优势皮试对支原体感染的特异性为100%。肺结核感染率为100%,MAC. M感染率为100%。禽流感显性皮肤试验可识别先前有MAC感染的受试者,并将其与M患者区分开来。结核病感染
The sensitivity and specificity of dual mycobacterial skin testing were assessed in an unblinded study of 22 patients with culture-confirmedMycobacterium aviumcomplex (MAC) infection and 20 patients with culture-confirmedMycobacterium tuberculosisinfection. Intradermal skin tests were performed with 0.1 mL ofM. aviumsensitin, 0.1 mL of PPD (purified protein derivative), and two control antigens (mumps andCandida). All patients withM. tuberculosisinfection reacted to the skin tests; the mean reaction size was 19.7 ± 1.4 mm when PPD was administered and 10.3 ± 1.5 mm whenM. aviumsensitin was administered. Four patients with MAC were anergic; for the remaining 18, mean reactions of 15.2 ± 1.4 mm toM. aviumsensitin and 4.3 ± 1.3 mm to PPD were noted. A skin test was defined asM. avium-dominant or PPD (M. tuberculosis) -dominant if there was a minimum reaction size of ⩾5 mm to the given species, and the reaction to the given species was ⩾3 mm greater than the reaction to the heterologous species. Dominant skin test reactions were present in 18 (90%) of 20 patients withM. tuberculosisand 15 (83%) of 18 nonanergic patients with MAC. The specificity of dominant skin tests was 100% for infection withM. tuberculosisand 100% for infection with MAC.M. avium-dominant skin tests identify subjects with prior MAC infection and distinguish them from patients withM. tuberculosisinfection.
使用重组胞内分枝杆菌抗原进行皮肤测试。
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