Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.
Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.
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DOI：
10.1016/j.stem.2015.05.009
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发表时间：
2015-06-04
期刊：
影响因子：
23.9
通讯作者：
Rossi, Derrick J.
中科院分区：
文献类型：
--
作者：
Beerman, Isabel;Rossi, Derrick J.
干细胞衰退是多种组织中衰老相关病理生理学的重要细胞驱动因素。表观遗传调控是建立和维持干细胞功能的核心，新的证据表明，表观遗传失调有助于干细胞在衰老过程中改变潜能。与终末分化的细胞不同，干细胞中表观遗传失调的影响超出了自身;除了通过自我更新分裂在干细胞库中延续和扩增外，改变还可以遗传地传递给分化的后代。本文综述了近年来有关组织特异性干细胞在稳态、衰老和衰老相关疾病中的表观遗传调控的研究。
Stem cell decline is an important cellular driver of aging-associated pathophysiology in multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell function, and emerging evidence indicates that epigenetic dysregulation contributes to the altered potential of stem cells during aging. Unlike terminally differentiated cells, the impact of epigenetic dysregulation in stem cells is propagated beyond self; alterations can be heritably transmitted to differentiated progeny, in addition to being perpetuated and amplified within the stem cell pool through self-renewal divisions. This review focuses on recent studies examining epigenetic regulation of tissue-specific stem cells in homeostasis, aging, and aging-related disease.
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影响因子：
3.7
作者：
Bocklandt S;Lin W;Sehl ME;Sánchez FJ;Sinsheimer JS;Horvath S;Vilain E
通讯作者：
Vilain E
影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
4.5
作者：
Christensen BC;Houseman EA;Marsit CJ;Zheng S;Wrensch MR;Wiemels JL;Nelson HH;Karagas MR;Padbury JF;Bueno R;Sugarbaker DJ;Yeh RF;Wiencke JK;Kelsey KT
通讯作者：
Kelsey KT
影响因子：
50.3
作者：
Abdel-Wahab O;Adli M;LaFave LM;Gao J;Hricik T;Shih AH;Pandey S;Patel JP;Chung YR;Koche R;Perna F;Zhao X;Taylor JE;Park CY;Carroll M;Melnick A;Nimer SD;Jaffe JD;Aifantis I;Bernstein BE;Levine RL
通讯作者：
Levine RL
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA