Sex differences in fetal Doppler parameters during gestation.
Sex differences in fetal Doppler parameters during gestation.
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DOI：
10.1186/s13293-021-00370-7
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发表时间：
2021-03-10
影响因子：
7.9
通讯作者：
Cahill LS
中科院分区：
文献类型：
--
作者：
Jagota D;George H;Walker M;Ravi Chandran A;Milligan N;Shinar S;Whitehead CL;Hobson SR;Serghides L;Parks WT;Baschat AA;Macgowan CK;Sled JG;Kingdom JC;Cahill LS
已知胎儿性别会影响妊娠结局。在目前的临床实践中，胎儿健康的监测是基于主要胎盘和胎儿血管的多普勒超声测量。本研究的目的是探讨健康妊娠期间胎儿性别对整个妊娠期间多普勒参数的影响。对240名妊娠妇女进行了一项前瞻性研究，在妊娠12至38周之间每隔4周进行一次超声检查。采集脐动脉（UA）、大脑中动脉（MCA）、腹主动脉降段（DAo）和静脉导管（DV）的脉冲多普勒频谱。线性混合效应模型用于确定这些血管的搏动指数（PI）是否取决于胎龄和胎儿性别。虽然雌性和雄性胎仔在妊娠期间的MCA PI和DV PIV无差异，但UA和DAo PI的轨迹因胎仔性别而异（分别为p = 0.02和p = 0.01）。多普勒超声参数被认为是依赖于胎儿性别的一些血管，而不是其他健康的怀孕。需要进一步的研究来了解这些性别差异的生理机制以及与妊娠期疾病过程的相关性。
Fetal sex is known to affect pregnancy outcomes. In current clinical practice, monitoring of fetal well-being is based on Doppler ultrasound measurements of major placental and fetal vessels. The objective of this study was to investigate the effect of fetal sex on Doppler parameters throughout gestation in healthy pregnancy. A prospective study was conducted in 240 pregnant women with ultrasound examinations at a 4-weekly interval between 12 and 38 weeks of gestation. Pulsed Doppler spectra were collected for the umbilical arteries (UAs), middle cerebral artery (MCA), descending abdominal aorta (DAo), and ductus venosus (DV). Linear mixed effects models were used to determine if the pulsatility indices (PIs) of these vessels depended on gestational age and fetal sex. While there were no differences in the MCA PI and DV PIV over gestation between female and male fetuses, the trajectory of the UA and DAo PIs differed by fetal sex (p = 0.02 and p = 0.01, respectively). Doppler ultrasound parameters were found to be dependent on fetal sex for some vessels and not for others in healthy pregnancies. Further investigations are needed to understand the physiological mechanisms for these sex differences and the relevance for disease processes in pregnancy.
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影响因子：
7.1
作者：
Bhide, A.;Acharya, G.;Trudinger, B.
通讯作者：
Trudinger, B.
影响因子：
4.3
作者：
Elsmen, Emma;Kallen, Karin;Hellstrom-Westas, Lena
通讯作者：
Hellstrom-Westas, Lena
影响因子：
3
作者：
Kiserud, T
通讯作者：
Kiserud, T
影响因子：
7.1
作者：
Owen, P;Murphy, J;Farrell, T
通讯作者：
Farrell, T
DOI：
10.1034/j.1600-0412.2001.080008702.x
发表时间：
2001-08-01
影响因子：
4.3
作者：
Madazli, R;Uludag, S;Ocak, V
通讯作者：
Ocak, V