Prevalence and predictors of hepatitis B virus (HBV) infection in east Africa: evidence from a systematic review and meta-analysis of epidemiological studies published from 2005 to 2020.
Prevalence and predictors of hepatitis B virus (HBV) infection in east Africa: evidence from a systematic review and meta-analysis of epidemiological studies published from 2005 to 2020.
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DOI：
10.1186/s13690-021-00686-1
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发表时间：
2021-09-18
期刊：
影响因子：
--
通讯作者：
Sendagire H
中科院分区：
文献类型：
--
作者：
Kafeero HM;Ndagire D;Ocama P;Kudamba A;Walusansa A;Sendagire H
东非普通人群中乙型肝炎病毒（HBV）的流行病学没有很好的文献记录。在这项荟萃分析中，我们检查了37篇完整发表的研究文章，以综合有关HBV负担的流行和预测因素的最新数据，从而有效地预防和管理我们地区的病毒。我们检查了2020年5月至10月期间在PubMed、Scopus、African Journal Online （AJOL）和谷歌Scholar上发现的37篇已发表的完整研究文章。从个体研究中提取HBV患病率和感染预测因子的二分法数据。使用MedCalc 19.1.3版软件计算HBV患病率、比例检验、相对危险度和I2异质性统计。Begg的检验被用来检验发表偏倚。通过敏感性分析、meta回归和亚组分析（95% CI）分析异质性来源。P < 0.05被认为是显著的。HBV的流行率普遍较高（6.025%），其中肯尼亚（8.54%）、乌干达（8.454%）和2011 - 2015年（8.759%）报告的流行率最高（P < 0.05）。输血、割伤、性乱交、HIV血清阳性和男性是HBV感染的独立预测因子（P < 0.05），其中男性是HBV感染的最强烈预测因子。合并HBV患病率和样本量以及发表年份的meta回归缺乏统计学意义（P < 0.05）。忽略样本量最大的研究使HBV总患病率略微增加至6.149%，表明这些研究是稳健的。Begg检验显示总体meta分析没有发表偏倚的证据（p < 0.05）。HBV的负担仍然很高，男性、输血、身体划伤和HIV血清阳性是感染的潜在预测因素。因此，重要的是要扩大针对高危人群的控制和预防措施。在线版本包含补充材料，可在10.1186/s13690-021-00686-1获得。
The epidemiology of hepatitis B virus (HBV) in the general population in east Africa is not well documented. In this meta-analysis, we examined 37 full published research articles to synthesise up-to-date data on the prevalence and predictors of the HBV burden for the effective prevention and management of the virus in our region. We examined 37 full published research articles found using PubMed, Scopus, African Journal Online (AJOL), and Google Scholar between May and October 2020. Dichotomous data on HBV prevalence and predictors of infection were extracted from the individual studies. The HBV prevalence, test of proportion, relative risk, and I2 statistics for heterogeneity were calculated using MedCalc software version 19.1.3. Begg’s tests was used to test for publication bias. Sources of heterogeneity were analysed through sensitivity analysis, meta-regression, and sub-group analysis at 95% CI. P < 0.05 was considered significant for all analyses. The prevalence of HBV was generally high (6.025%), with publications from Kenya (8.54%), Uganda (8.454%) and those from between 2011 and 2015 (8.759%) reporting the highest prevalence (P < 0.05). Blood transfusion, scarification, promiscuity, HIV seropositivity, and being male were independent predictors significantly associated with HBV infection (P < 0.05), with the male sex being the most strongly associated predictor of HBV infection. Meta-regressions for the pooled HBV prevalence and sample size, as well as the year of publication, lacked statistical significance (P > 0.05). Omitting the study with the largest sample size slightly increased pooled HBV prevalence to 6.149%, suggesting that the studies are robust. Begg’s test showed no evidence of publication bias for overall meta-analysis (p > 0.05). The burden of HBV is still high, with the male sex, blood transfusion, body scarification, and HIV seropositivity being potential predictors of infection. Thus, it is important to scale up control and prevention measures targeting persons at high risk. The online version contains supplementary material available at 10.1186/s13690-021-00686-1.
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影响因子：
5.5
作者：
Andersson, M. I.;Maponga, T. G.;Tedder, R. S.
通讯作者：
Tedder, R. S.
影响因子：
1
作者：
Baseke, Joy;Musenero, Monica;Mayanja-Kizza, Harriet
通讯作者：
Mayanja-Kizza, Harriet
影响因子：
3.8
作者：
Hawkins, Claudia;Christian, Beatrice;Fawzi, Wafaie
通讯作者：
Fawzi, Wafaie
影响因子：
1.8
作者：
Frambo AA;Atashili J;Fon PN;Ndumbe PM
通讯作者：
Ndumbe PM
DOI：
10.11604/pamj.2015.20.406.6206
发表时间：
2015
期刊：
The Pan African medical journal
影响因子：
--
作者：
Anaedobe CG;Fowotade A;Omoruyi CE;Bakare RA
通讯作者：
Bakare RA