Ribosome Specialization in Protozoa Parasites.
Ribosome Specialization in Protozoa Parasites.
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DOI：
10.3390/ijms24087484
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发表时间：
2023-04-19
影响因子：
5.6
通讯作者：
Karamysheva ZN
中科院分区：
文献类型：
--
作者：
Rodríguez-Almonacid CC;Kellogg MK;Karamyshev AL;Karamysheva ZN
核糖体一般被认为是蛋白质合成发生的组成性大分子机器;然而，这种观点最近受到了挑战，支持核糖体特化的假设，并开辟了一个全新的研究领域。最近的研究表明，核糖体在其性质上是异质的，并且可以通过调节翻译提供另一层基因表达控制。核糖体RNA和组成它们的核糖体蛋白质的异质性有利于选择性翻译不同的mRNA子库和功能特化。近年来，核糖体的异质性和特化在不同的真核生物研究模型中得到了广泛的报道，然而，关于这一主题的报道很少在原生动物，更少的原生动物寄生虫的医学重要性。本文分析了原生动物寄生虫中核糖体的异质性，强调其功能的专业化及其在寄生中的重要性，在其生命周期的各个阶段之间的过渡，在宿主的变化和对环境条件的反应。
Ribosomes, in general, are viewed as constitutive macromolecular machines where protein synthesis takes place; however, this view has been recently challenged, supporting the hypothesis of ribosome specialization and opening a completely new field of research. Recent studies have demonstrated that ribosomes are heterogenous in their nature and can provide another layer of gene expression control by regulating translation. Heterogeneities in ribosomal RNA and ribosomal proteins that compose them favor the selective translation of different sub-pools of mRNAs and functional specialization. In recent years, the heterogeneity and specialization of ribosomes have been widely reported in different eukaryotic study models; however, few reports on this topic have been made on protozoa and even less on protozoa parasites of medical importance. This review analyzes heterogeneities of ribosomes in protozoa parasites highlighting the specialization in their functions and their importance in parasitism, in the transition between stages in their life cycle, in the change of host and in response to environmental conditions.
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影响因子：
6.7
作者：
Carvalho CM;Santos AA;Pires SR;Rocha CS;Saraiva DI;Machado JP;Mattos EC;Fietto LG;Fontes EP
通讯作者：
Fontes EP
影响因子：
3.5
作者：
Avila CC;Mule SN;Rosa-Fernandes L;Viner R;Barisón MJ;Costa-Martins AG;Oliveira GS;Teixeira MMG;Marinho CRF;Silber AM;Palmisano G
通讯作者：
Palmisano G
影响因子：
3.8
作者：
Amiri-Dashatan, Nasrin;Rezaei-Tavirani, Mostafa;Ahmadi, Nayebali
通讯作者：
Ahmadi, Nayebali
DOI：
10.1126/science.aaa1193
发表时间：
2015-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Amunts A;Brown A;Toots J;Scheres SHW;Ramakrishnan V
通讯作者：
Ramakrishnan V
影响因子：
4.4
作者：
Mishra PC;Kumar A;Sharma A
通讯作者：
Sharma A