Topographic analysis of individual activation patterns in medial frontal cortex in schizophrenia.
Topographic analysis of individual activation patterns in medial frontal cortex in schizophrenia.
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DOI：
10.1002/hbm.20657
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发表时间：
2009-07
影响因子：
4.8
通讯作者：
Taylor, Stephan F.
中科院分区：
文献类型：
--
作者：
Stern, Emily R.;Welsh, Robert C.;Fitzgerald, Kate D.;Taylor, Stephan F.
神经激活位置的个体差异给神经影像学研究提出了一个独特的问题，神经影像学研究采用群体平均技术来研究认知和情感功能的神经基础。这对于检查患者群体的研究来说可能尤其具有挑战性，因为这些研究通常样本量有限且受试者间变异性增加。特别是，内侧额叶皮质（MFC）功能障碍被认为是患者表现监测功能障碍的基础，之前使用组平均进行的研究得出了相互矛盾的结果。为了检查与性能监测、干扰和错误处理两个方面相关的 MFC 中的个体激活，在 17 名精神分裂症患者和 21 名健康对照执行事件相关版本的多源干扰任务时，获取了功能磁共振成像 (fMRI) 数据。平均数据的比较显示各组之间几乎没有差异。相比之下，对个体错误激活的拓扑分析表明，对照受试者表现出跨越 MFC 后部和前部区域的激活，而患者主要激活后部 MFC，这可能反映了精神分裂症患者对错误的情绪反应受损。地形和组平均结果之间的这种差异可能是由于个体激活之间的显着分散造成的，特别是在健康对照之间，这凸显了在解释内侧额叶对错误行为的反应时考虑受试者间变异性的重要性。
Individual variability in the location of neural activations poses a unique problem for neuroimaging studies employing group averaging techniques to investigate the neural bases of cognitive and emotional functions. This may be especially challenging for studies examining patient groups, which often have limited sample sizes and increased intersubject variability. In particular, medial frontal cortex (MFC) dysfunction is thought to underlie performance monitoring dysfunction among patients with previous studies using group averaging to have yielded conflicting results. schizophrenia, yet compare schizophrenic patients to controls To examine individual activations in MFC associated with two aspects of performance monitoring, interference and error processing, functional magnetic resonance imaging (fMRI) data were acquired while 17 patients with schizophrenia and 21 healthy controls performed an event-related version of the multi-source interference task. Comparisons of averaged data revealed few differences between the groups. By contrast, topographic analysis of individual activations for errors showed that control subjects exhibited activations spanning across both posterior and anterior regions of MFC while patients primarily activated posterior MFC, possibly reflecting an impaired emotional response to errors in schizophrenia. This discrepancy between topographic and group-averaged results may be due to the significant dispersion among individual activations, particularly among healthy controls, highlighting the importance of considering intersubject variability when interpreting the medial frontal response to error commission.
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