Physiological, mitochondrial, and oxidative stress differences in the presence or absence of lactation in rats.
Physiological, mitochondrial, and oxidative stress differences in the presence or absence of lactation in rats.
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DOI：
10.1186/s12958-017-0317-7
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发表时间：
2018-01-09
期刊：
影响因子：
--
通讯作者：
Kavazis AN
中科院分区：
文献类型：
--
作者：
Hyatt HW;Zhang Y;Hood WR;Kavazis AN
人类流行病学数据显示，与分娩但不母乳喂养的母亲相比，母乳喂养降低了母亲患几种疾病的可能性，包括肥胖和II型糖尿病。本研究的目的是描述哺乳如何改变大鼠的身体组成、代谢、线粒体功能和氧化应激。将10周龄雌性sd大鼠分为3组（每组8只）：1)非生殖组（NR）， 2)允许交配分娩但不允许哺乳幼崽组（PP）， 3)允许交配分娩并哺乳至21日断奶组（PL）。所有动物在幼崽断奶后7天（即产后第28天）的相应时间被处死。PL大鼠体质量与NR大鼠相似，PP大鼠体质量高于NR大鼠。重要的是，与NR和PP大鼠相比，PL大鼠的腹膜后白色脂肪组织质量更低。脂肪量的差异伴随着更高的PPARδ、SOD2蛋白水平和氧化损伤的减少。此外，PL大鼠的肝脏具有更高的nadh连接底物的线粒体功能，PGC-1α、PPARδ和SOD2的表达也更高。在哺乳和不哺乳的雌性大鼠之间观察到的这些严重差异可以作为未来研究哺乳长期和持续益处的基础。
Human epidemiological data show that breastfeeding reduces the mother’s probability of developing several disease conditions, including obesity and type II diabetes compared to mothers that give birth but do not breastfeed. The goal of this investigation was to characterize how lactation changes a rat’s body composition, metabolism, mitochondrial function, and oxidative stress. Ten-week old female Sprague-Dawley rats were divided into three groups (n = 8 per group): 1) non-reproductive (NR), 2) those that were allowed to mate and give birth, but were not allowed to suckle their pups (PP), and 3) those that were allowed to mate and give birth, and suckled their young until weaning at 21 days (PL). All animals were sacrificed at a time corresponding to 7 days following the weaning of pups (i.e., day 28 postpartum). The body mass of PL rats was similar to NR rats, but the body mass of PP rats was higher than NR rats. Importantly, PL rats had lower retroperitoneal white adipose tissue mass compared to both NR and PP rats. The difference in fat mass was accompanied by higher protein levels of PPARδ, SOD2, and reduced oxidative damage. Furthermore, the liver of PL rats had higher mitochondrial function with NADH-linked substrates, and higher expression of PGC-1α, PPARδ, and SOD2. These acute differences observed between female rats that did and did not suckle their young could be used as the foundation for future research investigating the prolonged and sustained benefits of lactation.
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