Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women.
Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women.
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DOI：
10.1186/1475-2891-11-98
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发表时间：
2012-11-21
影响因子：
5.4
通讯作者：
Varady KA
中科院分区：
文献类型：
--
作者：
Klempel MC;Kroeger CM;Bhutani S;Trepanowski JF;Varady KA
间歇性禁食（IF;严重限制1天/周）有助于减轻体重，改善冠心病（CHD）风险指标。如果IF与卡路里限制（CR）和液体餐相结合，体重减轻的程度可以提高，仍然未知。本研究检查了IF加CR（有或没有流质饮食）对体重，身体成分和CHD风险的影响。肥胖妇女（n = 54）被随机分配到IFCR-液体（IFCR-L）或IFCR-食物为基础的（IFCR-F）饮食。试验分为两个阶段：1）2周体重维持期，2）8周体重减轻期。与IFCR-F组（2.5 ± 0.6 kg）相比，IFCR-L组（3.9 ± 1.4 kg）的体重下降更多（P = 0.04）。IFCR-L和IFCR-F组的脂肪量减少相似（P < 0.0001）（分别为2.8 ± 1.2 kg和1.9 ± 0.7 kg）。IFCR-L（0.7 ± 0.5 kg）和IFCR-F（0.3 ± 0.5 kg）饲料降低内脏脂肪（P < 0.001）。IFCR-L组（分别为19 ± 10%; 20 ± 9%）与IFCR-F组（分别为8 ± 3%; 7 ± 4%）相比，总胆固醇和LDL胆固醇水平的降低幅度更大（P = 0.04）。仅IFCR-L组LDL峰值粒径增加（P < 0.01），而心率、血糖、胰岛素和同型半胱氨酸降低（P < 0.05）。这些发现表明，IF结合CR和流食是帮助肥胖妇女减肥和降低CHD风险的有效策略。
Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk. Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period. Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 ± 1.4 kg) versus the IFCR-F group (2.5 ± 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 ± 1.2 kg and 1.9 ± 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 ± 0.5 kg) and IFCR-F (0.3 ± 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR-F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only. These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.
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影响因子：
4.9
作者：
Demerath, E. W.;Ritter, K. J.;Towne, B.
通讯作者：
Towne, B.
影响因子：
3.3
作者：
Avenell, A;Brown, TJ;Smith, WCS
通讯作者：
Smith, WCS
影响因子：
5.1
作者：
Juhaeri;Stevens, J;Cai, JW
通讯作者：
Cai, JW
影响因子：
7.1
作者：
Demerath, Ellen W.;Reed, Derek;Towne, Bradford
通讯作者：
Towne, Bradford
影响因子：
16.2
作者：
Williams, KV;Mullen, ML;Wing, RR
通讯作者：
Wing, RR