Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression.
Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression.
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DOI：
10.1016/j.pscychresns.2008.03.012
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发表时间：
2009-03-31
影响因子：
2.3
通讯作者：
Dzemidzic, Mario
中科院分区：
文献类型：
--
作者：
Anand, Amit;Li, Yu;Wang, Yang;Lowe, Mark J.;Dzemidzic, Mario
本研究首次调查了未用药双相情感障碍(BD)患者的静息状态皮质边缘连接异常，并将其与健康对照组和单相重度抑郁障碍(MDD)患者组的结果进行了比较。从先验确定的前扣带回皮质(PgACC)、背内侧丘脑(DMTHAL)、苍白质纹状体(PST)和杏仁核(AMYG)的感兴趣区(ROI)获取fMRI回波平面低频波幅(LFBF)的静息状态相关性，并与健康对照组和MDD患者进行比较。数据来自11名未服药的BD患者[6名躁狂(BDM)和5名抑郁(BDD)]，并与15名未服药的MDD和15名健康受试者的数据进行比较。BD患者与左侧和右侧DMTHAL的pgACC连接性显著降低，与MDD的发现相似。此外，BD患者与左侧和右侧AMYG以及左侧PST的pgACC连接性降低。一项探索性分析显示，BDD和BDM患者的pgACC和DMTHAL之间的连接性降低。研究结果表明，在不同类型的情绪障碍中，皮质边缘功能连接性降低是一个共同的发现。
This study for the first time investigated resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder (BD) and compared them with findings in healthy controls and unipolar major depressive disorder (MDD) patient groups. Resting state correlations of low frequency BOLD fluctuations (LFBF) in echoplanar functional magnetic resonance (fMRI) data were acquired from a priori defined regions of interests (ROIs) in the pregenual anterior cingulate cortex (pgACC), dorsomedial thalamus (DMTHAL), pallidostriatum (PST) and amygdala (AMYG), to investigate corticolimbic functional connectivity in unmedicated BD patients in comparison to healthy subjects and MDD patients. Data were acquired from 11 unmedicated BD patients [six manic (BDM) and five depressed (BDD)], and compared with data available from 15 unmedicated MDD and 15 healthy subjects. BD patients had significantly decreased pgACC connectivity to the left and right DMTHAL, similar to findings seen in MDD. Additionally, BD patients had decreased pgACC connectivity with the left and right AMYG as well as the left PST. An exploratory analysis revealed that both BDD and BDM patients had decreased connectivity between the pgACC and DMTHAL. The results of the study indicate a common finding of decreased corticolimbic functional connectivity in different types of mood disorders.
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影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
17.7
作者：
Blumberg, HP;Martin, A;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
--
作者：
Chang, K;Adleman, NE;Reiss, A
通讯作者：
Reiss, A
影响因子：
17.7
作者：
Altshuler, L;Bookheimer, S;Cohen, MS
通讯作者：
Cohen, MS