Heat Shock Proteins in Alzheimer's Disease: Role and Targeting.
Heat Shock Proteins in Alzheimer's Disease: Role and Targeting.
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DOI：
10.3390/ijms19092603
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发表时间：
2018-09-01
影响因子：
5.6
通讯作者：
Palumbo Piccionello A
中科院分区：
文献类型：
--
作者：
Campanella C;Pace A;Caruso Bavisotto C;Marzullo P;Marino Gammazza A;Buscemi S;Palumbo Piccionello A
阿尔茨海默病（Alzheimer's diseases，AD）是一种严重的医学和社会问题，至今尚未被完全治愈。AD研究中的一个主要问题是所涉及的生物化学途径的复杂性，包括蛋白质错误折叠的性质，这导致有毒物质的产生。考虑到AD病因学中的（错误）折叠过程的参与，靶向分子伴侣代表了有前途的治疗前景。本文分析了AD与分子伴侣之间的联系，特别关注作为人类伴侣组的代表性组分的最重要的热休克蛋白（HSPs）：HSP60，HSP70和HSP90。从生物学的角度强调了这些蛋白在AD中的作用。这种热休克蛋白与抑制剂或调节剂的药理学靶向也进行了讨论。
Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed.
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