Default mode network interference in mild traumatic brain injury - a pilot resting state study.
Default mode network interference in mild traumatic brain injury - a pilot resting state study.
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DOI：
10.1016/j.brainres.2013.08.034
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发表时间：
2013-11-06
期刊：
影响因子：
2.9
通讯作者：
Gullapalli RP
中科院分区：
文献类型：
--
作者：
Sours C;Zhuo J;Janowich J;Aarabi B;Shanmuganathan K;Gullapalli RP
在这项研究中，我们调查了功能连接在23轻度TBI（mTBI）患者和无记忆投诉使用静息状态功能磁共振成像在亚急性损伤阶段，以及一组对照参与者。结果表明，在自动神经心理评估量表（ANAM）评估记忆的测试中，有记忆投诉的mTBI患者的表现明显不如无记忆投诉的患者。在默认模式网络（DMN）和任务阳性网络（TPN）的节点之间的三组之间观察到改变的功能连接。在TPN和DMN以及与显著性网络（SN）相关的节点之间也观察到功能连接的改变。在mTBI之后，对于那些有和没有DMN记忆投诉的患者，反相关网络都有所减少，但对于TPN记忆投诉的mTBI患者，反相关网络仅有所减少。此外，TPN和SN之间的功能连接性增加似乎与记忆评估性能降低相关。总体而言，结果表明，静息时DMN和TPN分离的破坏可能通过TPN和DMN各节点之间FC增加的直接途径以及通过SN节点连接TPN和DMN的间接途径介导。网络之间的这种中断可能会对mTBI后的记忆功能造成不利影响，支持mTBI相关记忆缺陷背景下的默认模式干扰假说。
In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. Results indicate that mTBI patients with memory complaints performed significantly worse than patients without memory complaints on tests assessing memory from the Automated Neuropsychological Assessment Metrics (ANAM). Altered functional connectivity was observed between the three groups between the default mode network (DMN) and the nodes of the task positive network (TPN). Altered functional connectivity was also observed between both the TPN and DMN and nodes associated with the Salience Network (SN). Following mTBI there is a reduction in anti-correlated networks for both those with and without memory complaints for the DMN, but only a reduction in the anti-correlated network in mTBI patients with memory complaints for the TPN. Furthermore, an increased functional connectivity between the TPN and SN appears to be associated with reduced performance on memory assessments. Overall the results suggest that a disruption in the segregation of the DMN and the TPN at rest may be mediated through both a direct pathway of increased FC between various nodes of the TPN and DMN, and through an indirect pathway that links the TPN and DMN through nodes of the SN. This disruption between networks may cause a detrimental impact on memory functioning following mTBI, supporting the Default Mode Interference Hypothesis in the context of mTBI related memory deficits.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
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影响因子：
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作者：
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影响因子：
5.3
作者：
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影响因子：
9.9
作者：
Kasahara, M.;Menon, D. K.;Stamatakis, E. A.
通讯作者：
Stamatakis, E. A.
影响因子：
1.9
作者：
Kwok, Florence Y.;Lee, Tatia M. C.;Poon, Wai S.
通讯作者：
Poon, Wai S.