Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression.
Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression.
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DOI：
10.1016/j.jad.2018.09.065
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发表时间：
2019-01-15
影响因子：
6.6
通讯作者：
Dichter GS
中科院分区：
文献类型：
--
作者：
Walsh EC;Eisenlohr-Moul TA;Minkel J;Bizzell J;Petty C;Crowther A;Carl H;Smoski MJ;Dichter GS
抗抑郁药反应的神经生物学预测指标可能有助于指导治疗选择，并提高对严重抑郁障碍(MDD)现有治疗的应答率。抑郁症的行为激活疗法(BATD)是一种基于证据的干预措施，旨在通过促进持续参与以价值为导向、积极强化的活动来改善MDD的核心症状。本研究检验了治疗前基于任务的脑功能连接作为BATD抗抑郁反应的预测指标。33名患有MDD的门诊患者和20名非抑郁对照组在fMRI期间完成了一项积极的情绪调节任务，之后患有MDD的参与者接受了长达15次的BATD治疗。我们使用广义心理生理交互作用分析来检验在有意将积极情绪上调为积极图像期间，治疗前脑功能连接性的组间差异。分层线性模型被用来检验在BATD病程中，功能连接性的组间差异是否可以预测抑郁和快感缺乏的变化。与对照组相比，患有MDD的参与者在积极情绪的上调过程中，左额中回和右侧颞顶区域之间的连接性降低。在MDD组中，这些区域的连通性降低预示着在治疗过程中快感缺失症状的更大程度的下降。未来的研究应该包括对照治疗和纵向随访，以阐明BATD对神经功能和抗抑郁反应的独特影响。结果与之前的工作一致，表明BATD可能对大脑奖励网络功能障碍较大的个人特别有效，但扩展了这些发现，以强调额颞顶叶连接在针对动机和参与度低的症状方面的重要性。
Neurobiological predictors of antidepressant response may help guide treatment selection and improve response rates to available treatments for major depressive disorder (MDD). Behavioral activation therapy for depression (BATD) is an evidence-based intervention designed to ameliorate core symptoms of MDD by promoting sustained engagement with value-guided, positively-reinforcing activities. The present study examined pre-treatment task-based functional brain connectivity as a predictor of antidepressant response to BATD. Thirty-three outpatients with MDD and 20 nondepressed controls completed a positive emotion regulation task during fMRI after which participants with MDD received up to 15 sessions of BATD. We used generalized psychophysiological interaction analyses to examine group differences in pre-treatment functional brain connectivity during intentional upregulation of positive emotion to positive images. Hierarchical linear models were used to examine whether group differences in functional connectivity predicted changes in depression and anhedonia over the course of BATD. Compared to controls, participants with MDD exhibited decreased connectivity between the left middle frontal gyrus and right temporoparietal regions during upregulation of positive emotion. Within the MDD group, decreased connectivity of these regions predicted greater declines in anhedonia symptoms over treatment. Future studies should include comparison treatments and longitudinal follow-up to clarify the unique effects of BATD on neural function and antidepressant response. Results are consistent with previous work showing BATD may be particularly effective for individuals with greater disturbances in brain reward network function, but extend these findings to highlight the importance of frontotemporoparietal connectivity in targeting symptoms of low motivation and engagement.
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影响因子：
6.6
作者：
Smoski, Moria J.;Keng, Shian-Ling;Schiller, Crystal Edler;Minkel, Jared;Dichter, Gabriel S.
通讯作者：
Dichter, Gabriel S.
DOI：
10.1146/annurev-clinpsy-032210-104535
发表时间：
2011-01-01
影响因子：
18.4
作者：
Dimidjian, Sona;Barrera, Manuel, Jr.;Lewinsohn, Peter M.
通讯作者：
Lewinsohn, Peter M.
影响因子：
5.7
作者：
Cisler JM;Bush K;Steele JS
通讯作者：
Steele JS
影响因子：
3.7
作者：
Mars, Rogier B.;Sallet, Jerome;Rushworth, Matthew F. S.
通讯作者：
Rushworth, Matthew F. S.
影响因子：
6.6
作者：
Carl H;Walsh E;Eisenlohr-Moul T;Minkel J;Crowther A;Moore T;Gibbs D;Petty C;Bizzell J;Dichter GS;Smoski MJ
通讯作者：
Smoski MJ