Sustained anterior cingulate cortex activation during reward processing predicts response to psychotherapy in major depressive disorder.
Sustained anterior cingulate cortex activation during reward processing predicts response to psychotherapy in major depressive disorder.
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DOI：
10.1016/j.jad.2016.06.005
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发表时间：
2016-10
影响因子：
6.6
通讯作者：
Smoski MJ
中科院分区：
文献类型：
--
作者：
Carl H;Walsh E;Eisenlohr-Moul T;Minkel J;Crowther A;Moore T;Gibbs D;Petty C;Bizzell J;Dichter GS;Smoski MJ
本研究的目的是评估是否治疗前神经激活的奖励是抑郁症的行为激活疗法（BASD）的临床反应的预测，经验验证的心理治疗，减少抑郁症状，通过增加参与奖励刺激和减少回避行为。研究对象为33名门诊抑郁症患者和20名对照组。我们研究了激活的组间差异，以及维持激活的能力，跨任务运行使用功能磁共振成像（fMRI）和货币激励延迟（MID）任务。分层线性模型被用来调查是否治疗前的神经反应预测抑郁症状的变化，在整个过程中的BASD治疗。MDD组和对照组在右丘脑核的奖励结果期间的持续激活不同，因此MDD组相对于对照组在第一到第二次任务运行中经历了该区域激活的显著减少。治疗前快感缺失的严重程度和治疗前任务相关的反应时间是治疗反应的预测指标。此外，奖励结果期间前扣带皮层的持续激活可预测对心理治疗的反应;该区域持续激活程度更高的患者对BTD治疗反应更快。目前的研究仅包括一种治疗条件，因此尚不清楚这些治疗反应的预测因素是否特异于BTD或一般的心理治疗。研究结果增加了越来越多的文献表明，维持神经反应的奖励的能力可能是一个关键的内表型的MDD。
The purpose of the present investigation was to evaluate whether pre-treatment neural activation in response to rewards is a predictor of clinical response to Behavioral Activation Therapy for Depression (BATD), an empirically validated psychotherapy that decreases depressive symptoms by increasing engagement with rewarding stimuli and reducing avoidance behaviors. Participants were 33 outpatients with major depressive disorder (MDD) and 20 matched controls. We examined group differences in activation, and the capacity to sustain activation, across task runs using functional magnetic resonance imaging (fMRI) and the monetary incentive delay (MID) task. Hierarchical linear modeling was used to investigate whether pre-treatment neural responses predicted change in depressive symptoms over the course of BATD treatment. MDD and Control groups differed in sustained activation during reward outcomes in the right nucleus accumbens, such that the MDD group experienced a significant decrease in activation in this region from the first to second task run relative to controls. Pretreatment anhedonia severity and pretreatment task-related reaction times were predictive of response to treatment. Furthermore, sustained activation in the anterior cingulate cortex during reward outcomes predicted response to psychotherapy; patients with greater sustained activation in this region were more responsive to BATD treatment. The current study only included a single treatment condition, thus it unknown whether these predictors of treatment response are specific to BATD or psychotherapy in general. Findings add to the growing body of literature suggesting that the capacity to sustain neural responses to rewards may be a critical endophenotype of MDD.
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DOI：
10.1176/appi.ajp.2012.12010014
发表时间：
2013-02
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Heller AS;Johnstone T;Light SN;Peterson MJ;Kolden GG;Kalin NH;Davidson RJ
通讯作者：
Davidson RJ
影响因子：
5.9
作者：
Admon R;Pizzagalli DA
通讯作者：
Pizzagalli DA
影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
Markou A
影响因子：
4.9
作者：
Dichter GS;Damiano CA;Allen JA
通讯作者：
Allen JA
影响因子：
6.6
作者：
Alexopoulos, George S.;Hoptman, Matthew J.;Yuen, Genevieve;Kanellopoulos, Dora;Seirup, Joanna K.;Lim, Kelvin O.;Gunning, Faith M.
通讯作者：
Gunning, Faith M.