Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis.
Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis.
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DOI：
10.1016/j.jneuroim.2015.02.002
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发表时间：
2015-03-15
影响因子：
3.3
通讯作者：
Lampa, Jon
中科院分区：
文献类型：
--
作者：
Kosek, Eva;Altawil, Reem;Kadetoff, Diana;Finn, Anja;Westman, Marie;Le Maitre, Ervvan;Andersson, Magnus;Jensen-Urstad, Mats;Lampa, Jon
关键词：
本研究的目的是将中枢炎症与类风湿性关节炎（RA）和纤维肌痛（FM）患者的自主活动（心率变异性（HRV））联系起来。与健康对照组相比，RA患者的副交感神经活动减少，FM患者的交感神经活动增加。RA和FM之间的比较显示，RA中较高的脑脊液（CSF）白细胞介素（IL）-1β与副交感神经活性呈负相关。FM患者CSF中IL-8、IL-1 Ra、IL-4和IL-10浓度较高，但这些细胞因子均与HRV无关。总之，我们发现了不同的中央细胞因子谱，即，炎性疼痛（RA）中IL-1β升高，功能失调性疼痛（FM）中IL-8升高。纤维肌痛和类风湿性关节炎患者CSF中细胞因子/趋化因子的不同分布纤维肌痛患者CSF中IL-8、IL-1 Ra、IL-4和IL-10的浓度较高类风湿性关节炎患者CSF中IL-1 β的浓度较高类风湿性关节炎患者CSF中IL-1 β的浓度升高与副交感神经活性降低有关。
The purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced parasympathetic activity and FM patients had increased sympathetic activity compared to healthy controls. Comparisons between RA and FM showed higher cerebrospinal fluid (CSF) interleukin (IL)-1β inversely correlated to parasympathetic activity in RA. The FM patients had higher concentrations of CSF IL-8, IL-1Ra, IL-4 and IL-10, but none of these cytokines correlated with HRV. In conclusion, we found different profiles of central cytokines, i.e., elevated IL-1β in inflammatory pain (RA) and elevated IL-8 in dysfunctional pain (FM). Different CSF profiles of cytokines/chemokines in patients with fibromyalgia and rheumatoid arthritis Higher CSF concentrations of IL-8, IL-1Ra, IL-4 and IL-10 in fibromyalgia patients Higher CSF concentrations of IL-1beta in patients with rheumatoid arthritis Elevated CSF IL-1beta in rheumatoid arthritis was related to decreased parasympathetic activity.
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影响因子：
3.3
作者：
Chen, P;Shibata, M;Hofman, FM
通讯作者：
Hofman, FM
影响因子：
3.8
作者：
Ahn, DK;Lee, KR;Park, JS
通讯作者：
Park, JS
DOI：
10.1073/pnas.0409225102
发表时间：
2005-02-01
影响因子：
11.1
作者：
Cunha, TM;Verri, WA;Ferreira, SH
通讯作者：
Ferreira, SH
影响因子：
2.7
作者：
Holman, Andrew J.;Ng, Edmund
通讯作者：
Ng, Edmund
影响因子：
3.6
作者：
Kosek, E;Ordeberg, G
通讯作者：
Ordeberg, G