Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.
Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.
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DOI：
10.1016/j.healun.2022.06.018
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发表时间：
2022-10
影响因子：
8.9
通讯作者：
Wolfe, Cameron R.
中科院分区：
文献类型：
--
作者：
Eichenberger, Emily M.;Coniglio, Amanda C.;Milano, Carmelo;Schroder, Jacob;Bryner, Benjamin S.;Spencer, Philip J.;Haney, John C.;Klapper, Jacob;Glass, Carolyn;Pavlisko, Elizabeth;Dibernardo, Louis;Patel, Chetan B.;DeVore, Adam D.;Reynolds, John;Wolfe, Cameron R.
我们介绍了我们机构评估和移植新冠肺炎阳性捐赠者胸部器官的方案，并报告了迄今为止的结果。新冠肺炎检测呈阳性的供者心脏，只要在末期住院期间没有表现出高凝状态或新冠肺炎引起的高炎症状态，就有资格在我们的机构进行移植。如果捐赠者在捐献前20天首先对鼻咽拭子(NPS)新冠肺炎检测呈阳性，且下呼吸道标本为阴性，则符合条件。我们采用新冠肺炎阳性供者的器官，在13例受者中进行了14例胸部移植。没有一名接受者或医疗保健会员获得新冠肺炎。无一例受体发生意外的急性排斥反应。到目前为止，患者存活率为92%，移植物存活率为93%。使用新冠肺炎阳性捐赠者的心脏可能是安全有效的。肺移植尚未解决，但在受限的情况下可能会谨慎进行。
We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our institution provided the donor exhibited no evidence of hypercoagulability or COVID-19 induced hyperinflammatory state during terminal hospitalization. Lungs were eligible if the donor first tested PCR positive on nasopharyngeal swab (NPS) for COVID-19 > 20 days prior to procurement and had a negative lower respiratory tract specimen. We performed 14 thoracic transplants in 13 recipients using organs from COVID-19 positive donors. None of the recipients or healthcare members acquired COVID-19. No recipients suffered unexpected acute rejection. Patient survival is 92% to date, with graft survival 93%. The use of hearts from COVID-19 positive donors may be safe and effective. Transplantation of lungs is unresolved but may be cautiously pursued under the restricted circumstances.
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影响因子：
5.4
作者：
Ortega-Paz L;Capodanno D;Montalescot G;Angiolillo DJ
通讯作者：
Angiolillo DJ
DOI：
10.1111/tid.13503
发表时间：
2021-04
期刊：
Transplant infectious disease : an official journal of the Transplantation Society
影响因子：
--
作者：
Neidlinger NA;Smith JA;D'Alessandro AM;Roe D;Taber TE;Pereira MR;Friedman AL
通讯作者：
Friedman AL
影响因子：
2.1
作者：
Kute VB;Fleetwood VA;Meshram HS;Guenette A;Lentine KL
通讯作者：
Lentine KL
影响因子：
4.7
作者：
Bulfamante GP;Perrucci GL;Falleni M;Sommariva E;Tosi D;Martinelli C;Songia P;Poggio P;Carugo S;Pompilio G
通讯作者：
Pompilio G
影响因子：
8.8
作者：
Kaul, Daniel R.;Valesano, Andrew L.;Lauring, Adam S.
通讯作者：
Lauring, Adam S.