Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes.
Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes.
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DOI：
10.3390/genes9110566
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发表时间：
2018-11-21
期刊：
影响因子：
3.5
通讯作者：
Bashtrykov P
中科院分区：
文献类型：
--
作者：
Jeltsch A;Broche J;Bashtrykov P
DNA甲基化是表观基因组染色质修饰网络的重要组成部分，表观基因组染色质修饰网络还包括几种共价组蛋白翻译后修饰。所有这些修饰都是高度相互关联的，因为一个标记的写入者和擦除者，DNA甲基化的情况下的DNA甲基转移酶（DNMT）和10 - 11个易位酶（TMT），直接或间接地被其他标记靶向和调节。在这里，我们收集了关于人类和小鼠DNA中不同基因组元件中DNA甲基化的基因组分布和变异性的信息。在总结了DNA甲基化对基因组进化（包括CpG缺失）的影响后，我们描述了DNA甲基化与几种重要的组蛋白翻译后修饰（包括H3 K4、H3 K9、H3 K27和H3 K36的甲基化）以及核小体重塑的关系。此外，我们提出了哺乳动物DNA甲基转移酶及其相关因子介导DNA甲基化和染色质修饰之间的串扰的机制特征。最后，我们描述了最近的进展，关于非CpG位点的甲基化，人类细胞中腺嘌呤残基的甲基化和线粒体DNA甲基化。在几个地方，我们强调了有争议的发现或需要未来实验工作的开放问题。
DNA methylation is an essential part of the epigenome chromatin modification network, which also comprises several covalent histone protein post-translational modifications. All these modifications are highly interconnected, because the writers and erasers of one mark, DNA methyltransferases (DNMTs) and ten eleven translocation enzymes (TETs) in the case of DNA methylation, are directly or indirectly targeted and regulated by other marks. Here, we have collected information about the genomic distribution and variability of DNA methylation in human and mouse DNA in different genomic elements. After summarizing the impact of DNA methylation on genome evolution including CpG depletion, we describe the connection of DNA methylation with several important histone post-translational modifications, including methylation of H3K4, H3K9, H3K27, and H3K36, but also with nucleosome remodeling. Moreover, we present the mechanistic features of mammalian DNA methyltransferases and their associated factors that mediate the crosstalk between DNA methylation and chromatin modifications. Finally, we describe recent advances regarding the methylation of non-CpG sites, methylation of adenine residues in human cells and methylation of mitochondrial DNA. At several places, we highlight controversial findings or open questions demanding future experimental work.
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影响因子：
46.9
作者：
Ball, Madeleine P.;Li, Jin Billy;Gao, Yuan;Lee, Je-Hyuk;LeProust, Emily M.;Park, In-Hyun;Xie, Bin;Daley, George Q.;Church, George M.
通讯作者：
Church, George M.
DOI：
10.1038/nrm4043
发表时间：
2015-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Du J;Johnson LM;Jacobsen SE;Patel DJ
通讯作者：
Patel DJ
影响因子：
16
作者：
Charlet J;Duymich CE;Lay FD;Mundbjerg K;Dalsgaard Sørensen K;Liang G;Jones PA
通讯作者：
Jones PA
影响因子：
8.8
作者：
Fasching L;Kapopoulou A;Sachdeva R;Petri R;Jönsson ME;Männe C;Turelli P;Jern P;Cammas F;Trono D;Jakobsson J
通讯作者：
Jakobsson J
影响因子：
3.5
作者：
Ben-Shachar S;Chahrour M;Thaller C;Shaw CA;Zoghbi HY
通讯作者：
Zoghbi HY