Association Between Race/Ethnicity and COVID-19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID-19 Global Rheumatology Alliance.
Association Between Race/Ethnicity and COVID-19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID-19 Global Rheumatology Alliance.
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DOI：
10.1002/acr.25039
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发表时间：
2023-01
影响因子：
4.7
通讯作者：
Yazdany, Jinoos
中科院分区：
文献类型：
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作者：
Ugarte-Gil, Manuel F.;Alarcon, Graciela S.;Seet, Andrea M.;Izadi, Zara;Montgomery, Anna D.;Duarte-Garcia, Ali;Gilbert, Emily L.;Valenzuela-Almada, Maria O.;Wise, Leanna;Sparks, Jeffrey A.;Hsu, Tiffany Y. -T.;D'Silva, Kristin M.;Patel, Naomi J.;Sirotich, Emily;Liew, Jean W.;Hausmann, Jonathan S.;Sufka, Paul;Grainger, Rebecca;Bhana, Suleman;Wallace, Zachary;Jacobsohn, Lindsay;Strangfeld, Anja;Mateus, Elsa F.;Hyrich, Kimme L.;Gossec, Laure;Carmona, Loreto;Lawson-Tovey, Saskia;Kearsley-Fleet, Lianne;Schaefer, Martin;Machado, Pedro M.;Robinson, Philip C.;Gianfrancesco, Milena;Yazdany, Jinoos
目的：确定系统性红斑狼疮(SLE)患者的种族/民族与新冠肺炎预后之间的关联。数据在2020年3月24日至2021年8月27日期间输入新冠肺炎全球风湿病联盟注册表的美国系统性红斑狼疮患者被纳入其中。变量包括年龄、性别、种族和民族(白人、黑人、西班牙裔和其他)、合并症、疾病活动性、流行时间、糖皮质激素剂量、抗疟疾药物和免疫抑制药物的使用。结果依次为：未入院、无氧合入院、有无机械通气或氧合入院、死亡。我们构建了评估种族/民族与新冠肺炎严重程度之间关系的有序Logistic回归模型，调整了可能的混杂因素。523例患者中，女性473例(90.4%)，平均 ± SD年龄为46.6 ± 14.0 岁。未住院患者358例(74.6%)，无氧住院40例(8.3%)，有氧合住院的患者(13.3%)，死亡18例(3.8%)。在多变量模型中，黑人(优势比[OR]2.73[95%可信区间(95%CI)1.36-5.53])和西班牙裔(OR 2.76[95%CI 1.34-5.69])个体比白人个体发生更严重后果的几率更高。患有系统性红斑狼疮的黑人和西班牙裔患者经历了更严重的新冠肺炎结局，这与美国普通人群的研究结果一致。这些结果可能反映了社会经济和健康方面的差距，并表明需要作出更积极的努力来预防和治疗这一人群的感染。
To determine the association between race/ethnicity and COVID‐19 outcomes in individuals with systemic lupus erythematosus (SLE). Individuals with SLE from the US with data entered into the COVID‐19 Global Rheumatology Alliance registry between March 24, 2020 and August 27, 2021 were included. Variables included age, sex, race, and ethnicity (White, Black, Hispanic, other), comorbidities, disease activity, pandemic time period, glucocorticoid dose, antimalarials, and immunosuppressive drug use. The ordinal outcome categories were: not hospitalized, hospitalized with no oxygenation, hospitalized with any ventilation or oxygenation, and death. We constructed ordinal logistic regression models evaluating the relationship between race/ethnicity and COVID‐19 severity, adjusting for possible confounders. We included 523 patients; 473 (90.4%) were female and the mean ± SD age was 46.6 ± 14.0 years. A total of 358 patients (74.6%) were not hospitalized; 40 patients (8.3%) were hospitalized without oxygen, 64 patients (13.3%) were hospitalized with any oxygenation, and 18 (3.8%) died. In a multivariable model, Black (odds ratio [OR] 2.73 [95% confidence interval (95% CI) 1.36–5.53]) and Hispanic (OR 2.76 [95% CI 1.34–5.69]) individuals had higher odds of more severe outcomes than White individuals. Black and Hispanic individuals with SLE experienced more severe COVID‐19 outcomes, which is consistent with findings in the US general population. These results likely reflect socioeconomic and health disparities and suggest that more aggressive efforts are needed to prevent and treat infection in this population.
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影响因子：
13.8
作者：
Tan AX;Hinman JA;Abdel Magid HS;Nelson LM;Odden MC
通讯作者：
Odden MC
影响因子：
27.4
作者：
Ugarte-Gil, Manuel Francisco;Alarcon, Graciela S.;Yazdany, Jinoos
通讯作者：
Yazdany, Jinoos
影响因子：
4.7
作者：
Maningding, Ernest;Dall'Era, Maria;Yazdany, Jinoos
通讯作者：
Yazdany, Jinoos
DOI：
10.1002/art.41567
发表时间：
2021-03
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Gianfrancesco MA;Leykina LA;Izadi Z;Taylor T;Sparks JA;Harrison C;Trupin L;Rush S;Schmajuk G;Katz P;Jacobsohn L;Hsu TY;D'Silva KM;Serling-Boyd N;Wallwork R;Todd DJ;Bhana S;Costello W;Grainger R;Hausmann JS;Liew JW;Sirotich E;Sufka P;Wallace ZS;Machado PM;Robinson PC;Yazdany J;COVID-19 Global Rheumatology Alliance
通讯作者：
COVID-19 Global Rheumatology Alliance
DOI：
10.1097/phh.0000000000001263
发表时间：
2021-01-01
影响因子：
3.3
作者：
Chen, Jarvis T.;Krieger, Nancy
通讯作者：
Krieger, Nancy