Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog
Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog
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维生素 D 类似物对维生素 D 受体与转录辅激活剂的选择性相互作用
DOI：
10.1128/mcb.19.2.1049
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发表时间：
1999
影响因子：
5.3
通讯作者：
S. Kato
中科院分区：
文献类型：
--
作者：
K. Takeyama;Y. Masuhiro;Hiroaki Fuse;H. Endoh;A. Murayama;S. Kitanaka;M. Suzawa;J. Yanagisawa;S. Kato
ABSTRACT The nuclear vitamin D receptor (VDR) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor. A family of cotranscriptional activators (SRC-1, TIF2, and AIB-1) interacts with and activates the transactivation function of nuclear receptors in a ligand-dependent way. We examined interaction of VDR with these coactivators that was induced by several vitamin D analogs, since they exert differential subsets of the biological action of vitamin D through unknown mechanisms. Unlike other vitamin D analogs tested, OCT (22-oxa-1α,25-dihydroxyvitamin D3) induced interaction of VDR with TIF2 but not with SRC-1 or AIB-1. Consistent with these interactions, only TIF2 was able to potentiate the transactivation function of VDR bound to OCT. Thus, the present findings suggest that the structure of VDR is altered in a vitamin D analog-specific way, resulting in selective interactions of VDR with coactivators. Such selective interaction of coactivators with VDR may specify the array of biological actions of a vitamin D analog like OCT, possibly through activating a particular set of target gene promoters.
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影响因子：
20.3
作者：
R. Bouillon;W. Okamura;A. Norman
通讯作者：
R. Bouillon;W. Okamura;A. Norman
影响因子：
56.9
作者：
Feng, WJ;Ribeiro, RCJ;West, BL
通讯作者：
West, BL
维生素 D、钙和表皮分化。
影响因子：
20.3
作者：
Bikle,DD;Pillai,S
通讯作者：
Pillai,S
25-羟基-26,26,26,27,27,27-六氟维生素D3：在大鼠中的生物活性。
影响因子：
3.9
作者：
Tanaka,Y;Pahuja,DN;Wichmann,JK;DeLuca,HF;Kobayashi,Y;Taguchi,T;Ikekawa,N
通讯作者：
Ikekawa,N
DOI：
10.1073/pnas.93.10.4948
发表时间：
1996-05-14
影响因子：
11.1
作者：
Hong, H;Kohli, K;Stallcup, MR
通讯作者：
Stallcup, MR