Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping.
Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping.
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协作计算解剖学：通过微分同态度量映射对人脑进行 MRI 形态测量研究。
DOI：
10.1002/hbm.20655
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发表时间：
2009-07
影响因子：
4.8
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
--
作者：
Miller, Michael I.;Priebe, Carey E.;Qiu, Anqi;Fischl, Bruce;Kolasny, Anthony;Brown, Timothy;Park, Youngser;Ratnanather, J. Tilak;Busa, Evelina;Jovicich, Jorge;Yu, Peng;Dickerson, Bradford C.;Buckner, Randy L.
本文描述了一个大型的多机构分析的形状和结构的人类海马在老化的大脑中测量通过MRI。该研究纳入101名对照（n=57），临床痴呆评分（CDR）为0分，临床诊断为阿尔茨海默病（AD， 28名CDR为0.5分，10名CDR为1分）或语义性痴呆（SD， 4名CDR为0.5分，2名CDR为0分），影像学数据收集于圣路易斯华盛顿大学，海马结构在马萨诸塞州总医院注释。以及利用大变形微分同构映射（LDDMM）嵌入度量形状空间的解剖形状。构建了一个全局分类器，用于区分非痴呆（CDR 0）和痴呆（CDR 0.5或1）受试者，该分类器基于由LDDMM度量形状测量的解剖形状之间的度量距离得出的维度进行线性判别分析（p < 0.01）。对照和AD受试者仅在群体模板坐标上的局部分析显示，AD患者的耻骨下和CA1子场的形状发生了变化（p < 0.05）。这种对解剖形状的大规模协作分析有可能增强对神经发育和神经精神疾病的理解。
This paper describes a large multi-institutional analysis of the shape and structure of the human hippocampus in the aging brain as measured via MRI. The study was conducted on a population of 101 controls (n=57) with Clinical Dementia Rating (CDR) score 0 and subjects clinically diagnosed with Alzheimer’s Disease (AD, 28 with CDR 0.5 and 10 with CDR 1) or semantic dementia (SD, 4 with CDR 0.5 and 2 with CDR 0) with imaging data collected at Washington University in St. Louis, hippocampal structure annotated at the Massachusetts General Hospital, and anatomical shapes embedded into a metric shape space using large deformation diffeomorphic mapping (LDDMM) at the Johns Hopkins University. A global classifier was constructed for discriminating cohorts of nondemented (CDR 0) and demented (CDR 0.5 or 1) subjects based on linear discriminant analysis of dimensions derived from metric distances between anatomical shapes demonstrating class conditional structure measured via LDDMM metric shape (p < .01). Localized analysis of the control and AD subjects only on the coordinates of the population template demonstrates shape changes in the subiculum and the CA1 subfield in AD (p < .05). Such large scale collaborative analysis of anatomical shapes has the potential to enhance the understanding of neurodevelopmental and neuropsychiatric disorders.
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DOI：
10.1023/b:visi.0000043755.93987.aa
发表时间：
2005-02-01
影响因子：
19.5
作者：
Beg, MF;Miller, MI;Younes, L
通讯作者：
Younes, L
影响因子：
5.7
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
影响因子：
9.9
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
影响因子：
5.7
作者：
Fischl, B;Salat, DH;Dale, AM
通讯作者：
Dale, AM
影响因子：
--
作者：
Fotenos, Anthony F.;Mintun, Mark A.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.