Nutrition and autoimmune disease.
Nutrition and autoimmune disease.
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营养与自身免疫性疾病。
DOI：
10.1111/j.1753-4887.1998.tb01635.x
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发表时间：
1998
影响因子：
6.1
通讯作者：
Jolly,CA
中科院分区：
文献类型：
--
作者：
Fernandes,G;Jolly,CA
Interest in the use of polyunsaturated 0-3 fatty acids is rising very rapidly. The National Library of Medicine has cited 1108 articles between June 1993 and January 1995 (Wikes 1995) reporting several favorable results using 0-3 lipids in human and animal studies of autoimmune disorders, cardiovascular disease, diabetes, kidney disease, and neoplasia. Many of these studies used more refined oils with antioxidant supplementation to prevent lipid peroxidation. The United States consumes more than 1 billion pounds of fatdyear, and 91% of these fats are of plant origin (Chung and Pomeranz 1983). Total fat consumption remains 170 g/day. The use of hydrogenated fats and vegetable oils containing 0-6 fatty acids has increased dramatically because of their better taste and significantly lower cost compared with other oils, such as canola or olive oils (Raper et al. 1992), and because 0-6 lipids are regarded as beneficial in reducing cholesterol andLDL lipids (Eaton 1992, Willett 1994, Enig et al. 1983). Omega-3 fatty acids from plants (rich in 18: 3) or fish oil (FO)(rich in 2 0 5 and 22: 6 fatty acids) are consumed in much smaller amounts, mainly because 0-3 lipids, particularly those from marine sources, have a less pleasing taste and/or smell, are susceptible to oxidation, and have a short shelf life. Improved technology yielding odor-free oils and the addition of appropriate antioxidants to enhance storage and shelf life should increase the appeal of 0-3 lipids. The use of odorless FO dietary supplements in a hydrogenated or highly concentrated form along with other vegetable oils is under evaluation by the FDA (Young 1989).Systemic lupus erythematosus (SLE) is classified as one ofthe autoimmune rheumatic diseases. It is a chronic, systemic, inflammatory disease. It is estimated that more than 1 million people, mostly women, have SLE in the USA. Although SLE has been considered to be primarily a B cell disease, recent studies suggest that many autoimmune disorders, including SLE, involve T cell-dependent defects, specifically memory (TH-2 like) T cells, which become activated by cross-reactive antigens and contribute to the production of autoantibodies by B cells. An even
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活化 T 淋巴细胞原代培养物中的二酰基甘油和神经酰胺动力学。
影响因子：
4.4
作者：
C. Jolly;J. C. Laurenz;D. Mcmurray;R. Chapkin
通讯作者：
R. Chapkin
维生素 E、免疫反应和抗病能力
影响因子：
5.2
作者：
R. Tengerdy
通讯作者：
R. Tengerdy
Fas 抗原介导的 DNA 片段化和细胞凋亡形态变化受胞质 Ca2 水平升高的调节。
影响因子：
4.4
作者：
Y. Oshimi;S. Miyazaki
通讯作者：
S. Miyazaki
通过提高 cAMP 来预防 TCR 介导的细胞凋亡。
影响因子：
4.4
作者：
Sumio Hoshi;Makoto Furutani;Masao Seto;Tomio Tada;Yoshihiro Asano
通讯作者：
Yoshihiro Asano
热量限制可调节 MRL/lpr 小鼠的淋巴细胞亚群表型并增加细胞凋亡。
影响因子：
4.4
作者：
Luan,X;Zhao,W;Chandrasekar,B;Fernandes,G
通讯作者：
Fernandes,G