Neural correlates of own name and own face detection in autism spectrum disorder.
Neural correlates of own name and own face detection in autism spectrum disorder.
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DOI：
10.1371/journal.pone.0086020
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Nowicka A
中科院分区：
文献类型：
--
作者：
Cygan HB;Tacikowski P;Ostaszewski P;Chojnicka I;Nowicka A
自闭症谱系障碍（ASD）是一种异质性神经发育疾病，临床上以社会交往和沟通困难为特征。迄今为止，大多数研究工作都集中在与ASD相关的人际社会认知缺陷的大脑机制上。最近的经验和理论工作已经开始揭示ASD患者自我偏好效应减少甚至不存在的证据。我们可以假设这与自我参照刺激的注意加工受损有关。我们研究的目的就是为了验证这一假设。我们研究了ASD中面孔和名字检测的神经相关性。四个类别的脸/名称刺激：自己的，密切的其他，著名的，和未知的。在23例ASD患者和23例正常对照者的62个电极上记录事件相关电位。分析了P100、N170和P300组分。对照组明显表现出明显的自我偏好效应：对自己的面孔和名字的呈现比对亲近他人、著名和未知类别的呈现具有更高的P300幅值，表明在处理自我相关信息时存在优先注意参与。与此相反，在ASD组中，对自己和亲密他人的面孔和名字的检测与增强的P300相关，这表明对自我和亲密他人相关信息的注意力分配相似。这些研究结果表明，在ASD组的注意分配调制的个人意义因素，自我偏好的影响是不存在的，如果自我相比，密切的其他。这些影响对于自闭症自我的身体和非身体方面是相似的。此外，在ASD中，面孔和名字处理的偏侧化减弱，表明非典型的大脑组织。
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition clinically characterized by social interaction and communication difficulties. To date, the majority of research efforts have focused on brain mechanisms underlying the deficits in interpersonal social cognition associated with ASD. Recent empirical and theoretical work has begun to reveal evidence for a reduced or even absent self-preference effect in patients with ASD. One may hypothesize that this is related to the impaired attentional processing of self-referential stimuli. The aim of our study was to test this hypothesis. We investigated the neural correlates of face and name detection in ASD. Four categories of face/name stimuli were used: own, close-other, famous, and unknown. Event-related potentials were recorded from 62 electrodes in 23 subjects with ASD and 23 matched control subjects. P100, N170, and P300 components were analyzed. The control group clearly showed a significant self-preference effect: higher P300 amplitude to the presentation of own face and own name than to the close-other, famous, and unknown categories, indicating preferential attentional engagement in processing of self-related information. In contrast, detection of both own and close-other's face and name in the ASD group was associated with enhanced P300, suggesting similar attention allocation for self and close-other related information. These findings suggest that attention allocation in the ASD group is modulated by the personal significance factor, and that the self-preference effect is absent if self is compared to close-other. These effects are similar for physical and non-physical aspects of the autistic self. In addition, lateralization of face and name processing is attenuated in ASD, suggesting atypical brain organization.
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影响因子：
3.2
作者：
Dietrich, DE;Waller, C;Münte, TF
通讯作者：
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DOI：
10.1016/j.cogbrainres.2005.03.008
发表时间：
2005-08-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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Eimer, M