Model answers: Rational application of murine models in arthritis research.
Model answers: Rational application of murine models in arthritis research.
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DOI：
10.1002/eji.201746938
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发表时间：
2018-01
影响因子：
5.4
通讯作者：
Brewer JM
中科院分区：
文献类型：
--
作者：
Benson RA;McInnes IB;Garside P;Brewer JM
靶向免疫治疗的进展已经深刻地改善了炎性关节病特别是类风湿性关节炎患者的临床结果。观察到的疾病状况和期望的未来治疗结果也取得了进展。因此，越来越多的人开始脱离传统的终末期慢性疾病模型，认识到需要将发病的早期阶段作为治疗目标，从而解决和/或治愈疾病。为了继续发现过程，提高我们对疾病和治疗的理解，因此我们需要不断地重新审视我们使用的动物模型，并根据当代治疗目标评估它们的相关性和实用性。在这篇综述中，我们强调了我们认为动物模型的新发展及其应用最需要的领域。因此，我们将相关的小鼠模型及其在当前人类炎症性关节炎发病机制和突出需要领域的概念中的应用置于背景下。
Advances in targeted immune therapeutics have profoundly improved clinical outcomes for patients with inflammatory arthropathies particularly rheumatoid arthritis. The landscape of disease that is observed and the treatment outcomes desired for the future have also progressed. As such there is an increasing move away from traditional models of end‐stage, chronic disease with recognition of the need to consider the earliest phases of pathogenesis as a target for treatment leading to resolution and/or cure. In order to continue the discovery process and enhance our understanding of disease and treatment, we therefore need to continuously revisit the animal models we employ and assess their relevance and utility in the light of contemporary therapeutic goals. In this review, we highlight the areas where we consider new developments in animal models and their application are most required. Thus, we have contextualised the relevant mouse models and their use within the current concepts of human inflammatory arthritis pathogenesis and highlight areas of need.
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影响因子：
32.4
作者：
Kontoyiannis, D;Pasparakis, M;Kollias, G
通讯作者：
Kollias, G
影响因子：
7.3
作者：
Barone F;Gardner DH;Nayar S;Steinthal N;Buckley CD;Luther SA
通讯作者：
Luther SA
DOI：
10.1007/s00281-003-0125-3
发表时间：
2003-08-01
期刊：
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
影响因子：
--
作者：
Li, P;Schwarz, EM
通讯作者：
Schwarz, EM
影响因子：
15.9
作者：
Abdollahi-Roodsaz, Shahla;Joosten, Leo A. B.;Van den Berg, Wim B.
通讯作者：
Van den Berg, Wim B.
影响因子：
14.8
作者：
Khachigian, Levon M.
通讯作者：
Khachigian, Levon M.