Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis.
Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis.
复制标题
DOI：
10.1038/s41598-017-07137-4
复制
发表时间：
2017-07-31
影响因子：
4.6
通讯作者：
Terao C
中科院分区：
文献类型：
--
作者：
Kuramoto N;Ohmura K;Ikari K;Yano K;Furu M;Yamakawa N;Hashimoto M;Ito H;Fujii T;Murakami K;Nakashima R;Imura Y;Yukawa N;Yoshifuji H;Taniguchi A;Momohara S;Yamanaka H;Matsuda F;Mimori T;Terao C
抗着丝粒抗体（ACA）是经典的抗核抗体（ANA）染色模式之一。然而，ACA与其他ANA模式和ACA阳性受试者的临床特征相比，其特征尚未阐明。在这里，我们检查了所有ANA模式的间接免疫荧光859类风湿关节炎（RA）患者。结合9，575名健康志愿者的ANA数据，我们比较了ANA水平的分布。ACA是唯一的ANA，表现出明确的双峰分布水平。ACA在RA和健康人群中均显著高于其他ANA染色模式（p < 0.0001）。ACA阳性与老年有关，在女性中观察到更多。我们进一步招募了另一组3,353例RA患者，并证实了这一发现。ACA也与RA的雷诺现象相关（p = 6.8 × 10−11）。ACA阳性RA与ANA呈双峰分布，ACA阳性RA可能构成一个具有特异性临床特征的亚群。
Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3,353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features.
登录
查看更多内容
DOI：
10.1002/art.39306
发表时间：
2015-12
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Terao C;Yamakawa N;Yano K;Markusse IM;Ikari K;Yoshida S;Furu M;Hashimoto M;Ito H;Fujii T;Ohmura K;Murakami K;Takahashi M;Hamaguchi M;Tabara Y;Taniguchi A;Momohara S;Raychaudhuri S;Allaart CF;Yamanaka H;Mimori T;Matsuda F
通讯作者：
Matsuda F
影响因子：
4.9
作者：
Innala, Lena;Berglin, Ewa;Wallberg-Jonsson, Solveig
通讯作者：
Wallberg-Jonsson, Solveig
影响因子：
27.4
作者：
Terao C;Kawaguchi T;Dieude P;Varga J;Kuwana M;Hudson M;Kawaguchi Y;Matucci-Cerinic M;Ohmura K;Riemekasten G;Kawasaki A;Airo P;Horita T;Oka A;Hachulla E;Yoshifuji H;Caramaschi P;Hunzelmann N;Baron M;Atsumi T;Hassoun P;Torii T;Takahashi M;Tabara Y;Shimizu M;Tochimoto A;Ayuzawa N;Yanagida H;Furukawa H;Tohma S;Hasegawa M;Fujimoto M;Ishikawa O;Yamamoto T;Goto D;Asano Y;Jinnin M;Endo H;Takahashi H;Takehara K;Sato S;Ihn H;Raychaudhuri S;Liao K;Gregersen P;Tsuchiya N;Riccieri V;Melchers I;Valentini G;Cauvet A;Martinez M;Mimori T;Matsuda F;Allanore Y
通讯作者：
Allanore Y
影响因子：
3.7
作者：
Terao C;Ohmura K;Ikari K;Kochi Y;Maruya E;Katayama M;Yurugi K;Shimada K;Murasawa A;Honjo S;Takasugi K;Matsuo K;Tajima K;Suzuki A;Yamamoto K;Momohara S;Yamanaka H;Yamada R;Saji H;Matsuda F;Mimori T
通讯作者：
Mimori T
影响因子：
3.4
作者：
Pakunpanya, K;Verasertniyom, O;Janwityanujit, S
通讯作者：
Janwityanujit, S