The Body-wide Transcriptome Landscape of Disease Models.
The Body-wide Transcriptome Landscape of Disease Models.
复制标题
DOI：
10.1016/j.isci.2018.03.014
复制
发表时间：
2018-04-27
期刊：
影响因子：
5.8
通讯作者：
Sato TN
中科院分区：
文献类型：
--
作者：
Kozawa S;Ueda R;Urayama K;Sagawa F;Endo S;Shiizaki K;Kurosu H;Maria de Almeida G;Hasan SM;Nakazato K;Ozaki S;Yamashita Y;Kuro-O M;Sato TN
几乎所有疾病都会影响多个器官。然而，我们对全身影响的了解仍然有限。在这里，我们报告了心肌梗死，糖尿病，肾脏疾病，癌症和过早衰老的小鼠模型的13-23个器官的全身转录组景观。使用这些数据集，我们发现（1）在所有模型中不同器官中的差异基因表达;（2）皮肤作为疾病传感器器官，由推定的基因表达网络的疾病特异性活性表示;（3）骨源性激素FGF 23介导的骨-皮肤串扰，响应于磷酸盐稳态失调，这是肾脏疾病的已知风险因素;（4）疾病的许多假定的器官间串扰的特征活动的候选者;和（5）说明人和小鼠之间的器官与器官和模型与疾病关系的跨物种图谱。这些发现证明了这种涵盖不同疾病类型的小鼠模型的全身数据集作为生物和医学科学资源的有用性和潜力。此外，本文所述的发现可用于设计疾病诊断和治疗。涵盖不同疾病模型的全身多器官转录组数据集皮肤是疾病传感器器官，FGF 23介导疾病中的骨-皮肤串扰不同的假定器官间串扰选择性地与疾病相关说明小鼠-人类关系的跨物种图谱基因网络;系统生物学实验模型;转录组学
Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, kidney diseases, cancer, and pre-mature aging. Using such datasets, we find (1) differential gene expression in diverse organs across all models; (2) skin as a disease-sensor organ represented by disease-specific activities of putative gene-expression network; (3) a bone-skin cross talk mediated by a bone-derived hormone, FGF23, in response to dysregulated phosphate homeostasis, a known risk-factor for kidney diseases; (4) candidates for the signature activities of many more putative inter-organ cross talk for diseases; and (5) a cross-species map illustrating organ-to-organ and model-to-disease relationships between human and mouse. These findings demonstrate the usefulness and the potential of such body-wide datasets encompassing mouse models of diverse disease types as a resource in biological and medical sciences. Furthermore, the findings described herein could be exploited for designing disease diagnosis and treatment. Body-wide multi-organ transcriptome datasets encompassing diverse disease models Skin is a disease-sensor organ, and FGF23 mediates a bone-skin cross talk in diseases Diverse putative inter-organ cross talk selectively associates with diseases A cross-species map illustrating the mouse-human relationships Gene Network; Experimental Models in Systems Biology; Transcriptomics
登录
查看更多内容
影响因子：
13.2
作者：
Brewster, Ursula C.
通讯作者：
Brewster, Ursula C.
成纤维细胞生长因子 23 和骨矿化
影响因子：
14.9
作者：
Guo YC;Yuan Q
通讯作者：
Yuan Q
DOI：
10.1126/science.aad6970
发表时间：
2016-08-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Franzén O;Ermel R;Cohain A;Akers NK;Di Narzo A;Talukdar HA;Foroughi-Asl H;Giambartolomei C;Fullard JF;Sukhavasi K;Köks S;Gan LM;Giannarelli C;Kovacic JC;Betsholtz C;Losic B;Michoel T;Hao K;Roussos P;Skogsberg J;Ruusalepp A;Schadt EE;Björkegren JL
通讯作者：
Björkegren JL
DOI：
10.2337/diaclin.33.1.40
发表时间：
2015-01-01
期刊：
Clinical diabetes : a publication of the American Diabetes Association
影响因子：
--
作者：
Duff, Michelle;Demidova, Olga;Shubrook, Jay
通讯作者：
Shubrook, Jay
影响因子：
18.2
作者：
Hu MC;Shiizaki K;Kuro-o M;Moe OW
通讯作者：
Moe OW