D3 dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells
D3 dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells
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D3 多巴胺受体对肾近曲小管细胞 D5 受体表达和功能的调节
DOI：
10.1038/hr.2012.11
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发表时间：
2012-06
影响因子：
5.4
通讯作者：
Jose PA
中科院分区：
文献类型：
--
作者：
Zeng C;Ren H;Chen C;Yang J;Han Y;He D;Zhou L;Asico LD;Jose PA
多巴胺受体通过类D_1和类D_2受体增加肾脏的钠排泄。我们报道了肾近端小管(RPT)细胞中D3和D1受体之间的正相互作用.然而，这些报道并不排除D3和D5受体之间也可能存在相互作用，因为缺乏选择性的D1和D5受体激动剂或拮抗剂。我们推测D3受体可以调节D5受体，自发性高血压大鼠(SHR)RPTS中D5受体的D3受体调节功能受损。结果表明，D3受体激动剂PD128907通过激活蛋白激酶C活性，以浓度和时间依赖的方式增加Wistar-京都(WKY)大鼠RPT细胞D5受体的表达。SHR的RPT细胞中D3受体对D5受体表达的刺激作用减弱。D3受体对D5受体的作用与功能有关，刺激D5受体可降低WKY细胞的Na+-K+三磷酸腺苷酶(ATPase)活性。D3受体激动剂作用2 4h后，WKY细胞D5受体表达及D5受体对Na+-K+ATPase活性的抑制作用增强，而SHR细胞D5受体表达及D5受体对Na+-K+ATPase活性的抑制作用减弱。在转导D5受体的HEK293细胞中，D3受体对D5受体表达和功能的影响也得到证实。提示D3受体的激活增加了D5受体的表达和功能。D3受体对D5受体调节的改变可能在高血压的发病机制中起一定作用。
Dopamine receptor, via D 1-like and D 2-like receptors, increases sodium excretion in kidney. We have reported positive interactions between D 3 and D 1 receptors in renal proximal tubule (RPT) cells. These reports, however do not preclude that there may be also interaction between D 3 and D 5 receptors, because of the lack of selective D 1 and D 5 receptor agonists or antagonists. We hypothesize that D 3 receptors can regulate D 5 receptors, and that D 3 receptor regulation of D 5 receptors in RPTs is impaired in spontaneously hypertensive rats (SHRs). It showed that a D 3 receptor agonist, PD128907, by the activation of protein kinase C activity, increased the expression of D 5 receptors in a concentration-and time-dependent manner in RPT cells from Wistar-Kyoto (WKY) rats. The stimulatory effect of the D 3 receptor on D 5 receptor expression was impaired in RPT cells from SHRs. The effect of D 3 receptor on D 5 receptor is functionally relevant; stimulation of D 5 receptor decreases Na+–K+ adenosine triphosphatase (ATPase) activity in WKY cells. Pretreatment with D 3 receptor agonist for 24 h enhances the D 5 receptor expression and D 5 receptor-mediated inhibitory effect on Na+–K+ ATPase activity in WKY cells, but decreases them in SHR cells. The effect of D 3 receptor on D 5 receptor expression and function was also confirmed in the D 5 receptor-transfected HEK293 cells. It indicates that activation of D 3 receptor increases D 5 receptor expression and function. Altered regulation of D 3 receptor on D 5 receptors may have a role in the pathogenesis of hypertension.
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DOI：
10.1152/ajpregu.00600.2005
发表时间：
2006-03
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
R. Khalil
通讯作者：
R. Khalil
影响因子：
8.3
作者：
C. Zeng;Z. Wang;Hewang Li;P. Yu;S. Zheng;Li-juan Wu;L. Asico;U. Hopfer;G. Eisner;R. Felder;P. Jose
通讯作者：
C. Zeng;Z. Wang;Hewang Li;P. Yu;S. Zheng;Li-juan Wu;L. Asico;U. Hopfer;G. Eisner;R. Felder;P. Jose
DOI：
10.2174/187152507781058708
发表时间：
2007-06
影响因子：
--
作者：
C. Zeng;Zhiwei Yang;L. Asico;P. Jose
通讯作者：
C. Zeng;Zhiwei Yang;L. Asico;P. Jose
DOI：
10.1152/ajpregu.00434.2005
发表时间：
2006
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Zhiwei Yang;L. Asico;P. Yu;Z. Wang;J. Jones;C. Escano;Xiaoyan Wang;M. Quinn;D. Sibley;G. R
通讯作者：
Zhiwei Yang;L. Asico;P. Yu;Z. Wang;J. Jones;C. Escano;Xiaoyan Wang;M. Quinn;D. Sibley;G. R
DOI：
10.1152/ajpheart.01036.2007
发表时间：
2008-02
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
C. Zeng;I. Armando;Yingjin Luo;G. Eisner;R. Felder;P. Jose
通讯作者：
C. Zeng;I. Armando;Yingjin Luo;G. Eisner;R. Felder;P. Jose