Acetylcholine activity in selective striatal regions supports behavioral flexibility.
Acetylcholine activity in selective striatal regions supports behavioral flexibility.
复制标题
DOI：
10.1016/j.nlm.2008.09.008
复制
发表时间：
2009-01
影响因子：
2.7
通讯作者：
Roman, Suzanne
中科院分区：
文献类型：
--
作者：
Ragozzino, Michael E.;Mohler, Eric G.;Prior, Margaret;Palencia, Carlos A.;Roman, Suzanne
日常生活往往需要个人灵活地应对新的情况。有相当多的证据表明，纹状体是支持灵活适应的更大神经网络的一部分。胆碱能中间神经元的位置强烈影响纹状体的输出模式，这可能使灵活的适应。本实验通过测量位置反转学习过程中的乙酰胆碱流出量来研究不同纹状体区域的乙酰胆碱作用是否支持行为灵活性。乙酰胆碱流出选择性增加背内侧纹状体，但不背外侧或腹内侧纹状体在位置反转学习。为了调节M2类自身受体，将倍半富马酸氧震颤碱（100 nM）给药至背内侧纹状体，伴随着逆转学习受损和乙酰胆碱输出增加。这些作用被m2毒蕈碱受体拮抗剂AF-DX-116（20 nM）逆转。氧化震颤碱倍半富马酸盐和AF-DX-116对乙酰胆碱流出的影响对行为诱导的变化具有选择性，因为两种治疗都不影响静息状态下的乙酰胆碱输出。相反，逆转学习，乙酰胆碱流出的背内侧纹状体没有改变，在收购的地方。结果揭示了胆碱能活性的重要作用，并确定其控制点的背内侧纹状体的认知灵活性。
Daily living often requires individuals to flexibly respond to new circumstances. There is considerable evidence that the striatum is part of a larger neural network that supports flexible adaptations. Cholinergic interneurons are situated to strongly influence striatal output patterns which may enable flexible adaptations. The present experiments investigated whether acetylcholine actions in different striatal regions support behavioral flexibility by measuring acetylcholine efflux during place reversal learning. Acetylcholine efflux selectively increased in the dorsomedial striatum, but not dorsolateral or ventromedial striatum during place reversal learning. In order to modulate the M2-class of autoreceptors, administration of oxotremorine sesquifumurate (100 nM) into the dorsomedial striatum, concomitantly impaired reversal learning and an increase in acetylcholine output. These effects were reversed by the m2 muscarinic receptor antagonist, AF-DX-116 (20 nM). The effects of oxotremorine sesquifumurate and AF-DX-116 on acetylcholine efflux were selective to behaviorally-induced changes as neither treatment affected acetylcholine output in a resting condition. In contrast to reversal learning, acetylcholine efflux in the dorsomedial striatum did not change during place acquisition. The results reveal an essential role for cholinergic activity and define its locus of control to the dorsomedial striatum in cognitive flexibility.
登录
查看更多内容
影响因子：
5
作者：
DEBOER, P;WESTERINK, BHC;HORN, AS
通讯作者：
HORN, AS
影响因子：
2.7
作者：
McCool, Martha F.;Patel, Sima;Ragozzino, Michael E.
通讯作者：
Ragozzino, Michael E.
影响因子：
5.3
作者：
Crespo, Jose A.;Sturm, Katja;Zernig, Gerald
通讯作者：
Zernig, Gerald
影响因子：
2.5
作者：
DELGUANTE, MAD;CRUZMORALES, SE;PRADOALCALA, RA
通讯作者：
PRADOALCALA, RA
影响因子：
11
作者：
FLOWERS, KA;ROBERTSON, C
通讯作者：
ROBERTSON, C