A Possible Percutaneous Penetration Pathway That Should Be Considered.
A Possible Percutaneous Penetration Pathway That Should Be Considered.
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DOI：
10.3390/pharmaceutics9030026
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发表时间：
2017-07-27
期刊：
影响因子：
5.4
通讯作者：
Nakazawa H
中科院分区：
文献类型：
--
作者：
Hatta I;Ohta N;Nakazawa H
角质层中的细胞间脂质形成由具有正交和六边形烃链堆积结构的有序相组成的结构，此外，还形成由无序流体相组成的结构。尽管液相在经皮渗透中发挥着重要作用，但迄今为止文献中对此关注甚少。最近，提出了一种方法来估计角质层的脂质内的流体相的比例，并显示达到约80%。然而，由于该研究假设从角质层均匀提取细胞间脂质，因此该分析可能会高估液相中脂质的比例。我们开发了一种方法来调查的比例的脂质在流体相中，通过处理与乙醇，其中的脂质在流体相中可能会占主导地位的溶解。从实验中我们指出了液相中的脂质占整个细胞间脂质的50%以上的可能性。因此，在考虑经皮渗透机制时，应考虑细胞间脂质基质中的液相区域。
The intercellular lipids in the stratum corneum form structures composed of ordered phases with orthorhombic and hexagonal hydrocarbon-chain packing structures and, in addition, a structure composed of a disordered fluid phase. Although the fluid phase plays an important role in percutaneous penetration, little attention has been paid to it in the literature thus far. Recently, a method to estimate the proportion of the fluid phase within the lipids of the stratum corneum was proposed and it was shown to reach about 80%. However, since that study assumed uniform extraction of the intercellular lipids from the stratum corneum, the analysis might give rise to an overestimation of the proportion of the lipids in the fluid phase. We developed a way to investigate the proportion of the lipids in the fluid phase by treating with ethanol, into which the lipids in the fluid phase might be dominantly dissolved. From the experiment we pointed out the possibility that the proportion of the lipids in the fluid phase reached more than 50% of the whole intercellular lipids. Therefore, the fluid-phase region in the intercellular lipid matrix should be taken into account when considering the percutaneous penetration mechanism.
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影响因子：
6.5
作者：
BOUWSTRA, JA;GOORIS, GS;BRAS, W
通讯作者：
BRAS, W
影响因子：
3.4
作者：
Hatta, Ichiro;Nakazawa, Hiromitsu;Yagi, Naoto
通讯作者：
Yagi, Naoto
影响因子：
3.8
作者：
Tsai, JC;Sheu, HM;Cheng, CL
通讯作者：
Cheng, CL
影响因子：
6.5
作者：
YAMAMURA, T;TEZUKA, T
通讯作者：
TEZUKA, T
DOI：
10.1016/0005-2760(94)90252-6
发表时间：
1994-05-13
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM
影响因子：
--
作者：
BOUWSTRA, JA;GOORIS, GS;BRAS, W
通讯作者：
BRAS, W