Colonoscopic screening of persons with suspected risk factors for colon cancer. I. Family history.
Colonoscopic screening of persons with suspected risk factors for colon cancer. I. Family history.
复制标题
对疑似结肠癌危险因素的人进行结肠镜筛查。
DOI：
10.1016/0016-5085(88)90427-1
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Milos,ML
中科院分区：
文献类型：
--
作者：
Grossman,S;Milos,ML
结肠直肠癌的家族史被认为会增加人们患这种疾病的风险。然而，目前还不清楚家族史有多“强”才能增加这种风险或使结肠镜筛查合适。我们对154例无症状受试者进行了初始结肠镜检查，这些受试者唯一的疑似危险因素是一个或两个患有结直肠癌的一级亲属;其中48例受试者还患有二、三级亲属。我们发现45腺瘤28例（18%）。1例受试者有3 cm绒毛状腺瘤。在6例受试者中，最晚期的发现是直径为5-9 mm的管状腺瘤;在21例受试者中，我们仅发现直径为2-4 mm的管状腺瘤。腺瘤患病率随年龄增长而显著增加（p < 0.01）。虽然我们组中结直肠肿瘤的总体患病率并不高于一般人群的预期，但有两个一级亲属的受试者往往比有一个这样的亲属的受试者有更多的小腺瘤。我们的研究结果表明，结肠镜检查是不是一个适当的第一步，在筛选的人与一个受影响的一级亲属。对于那些有更复杂家族史的患者，需要更多的数据，特别是关于晚期肿瘤的患病率，以确定是否有一种比结肠镜检查更便宜、侵入性更小的筛查技术。
A family history of colorectal cancer is believed to place persons at increased risk for development of the disease. It is unclear, however, how “strong” a family history must be to increase this risk or to make colonoscopic screening appropriate. We performed initial colonoscopy in 154 asymptomatic subjects whose only suspected risk factor was one or two first-degree relatives with colorectal cancer; 48 of these subjects also had affected second- and third-degree relatives. We found 45 adenomas in 28 subjects (18%). One subject had a 3-cm villous adenoma. In 6 subjects, the most advanced findings were tubular adenomas 5–9 mm in diameter; in 21 subjects, we found only tubular adenomas that were 2–4 mm in diameter. The prevalence of adenomas increased significantly with age of subjects (p < 0.01). Although the overall prevalence of colorectal neoplasms in our group was no greater than might be expected in the general population, subjects with two first-degree relatives tended to have more diminutive adenomas than those with one such relative. Our findings suggest that colonoscopy is not an appropriate first step in screening persons with one affected first-degree relative. For those with more complex family histories, more data are needed—particularly on the prevalence of advanced neoplasms—to determine whether a screening technique that is less costly and less invasive than colonoscopy may be adequate.
登录
查看更多内容
影响因子：
6.2
作者：
R. Rickert;O. Auerbach;L. Garfinkel;E. Hammond;J. M. Frasca
通讯作者：
J. M. Frasca
遗传性非息肉病性结直肠癌（林奇综合征 I 和 II）。
影响因子：
6.2
作者：
H. Lynch;W. Kimberling;W. Albano;J. Lynch;Karen A. Biscone;G. Schuelke;A. Sandberg;M. Lipkin;E. Deschner;Y. Mikol;R. Elston;J. Bailey;B. Danes
通讯作者：
B. Danes
通过全结肠镜检查筛查结肠癌高危无症状患者
影响因子：
3.9
作者：
Paul VonRyll Gryska;A. Cohen
通讯作者：
A. Cohen
影响因子：
3.3
作者：
Botner, Anette;Broom, Donald;Wierup, Martin
通讯作者：
Wierup, Martin
临床生态遗传学：家族癌症。
影响因子：
158.5
作者：
J. Mulvihill
通讯作者：
J. Mulvihill