Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix.
Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix.
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DOI：
10.3802/jgo.2012.23.3.153
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发表时间：
2012-07
影响因子：
3.9
通讯作者：
Aoki D
中科院分区：
文献类型：
--
作者：
Murakami I;Fujii T;Kameyama K;Iwata T;Saito M;Kubushiro K;Aoki D
本研究的目的是探讨宫颈早期浸润性腺癌的风险和复发，并确定是否可以采用非根治性治疗方法。回顾了1993年至2005年在庆应义塾大学医院治疗的50例早期宫颈浸润性腺癌的医学和组织病理学记录，并与文献进行了比较。中位随访时间为64.3个月。间质浸润深度≤3mm 33例，≤3mm 17例；25例水平扩散≤7 mm， 25例水平扩散≤7 mm。肿瘤体积≤500 mm3的33例中有1例，肿瘤体积≤500 mm3的17例中有3例淋巴结转移阳性。当我们的数据与先前报道的结果相结合时，观察到肿瘤体积与盆腔淋巴结转移频率/复发率之间的统计学差异（p<0.0001）。淋巴血管腔浸润（LVSI）阳性组盆腔淋巴结转移频率明显高于LVSI阴性组（p=0.02）。未发现附件转移或参数累及。评估间质浸润深度、肿瘤体积和LVSI对于选择合适的治疗方式至关重要。对于间质浸润深度≤5mm、肿瘤体积≤500mm3的lvsi阴性宫颈腺癌患者，非根治性治疗方法被认为是合适的。
The aim of this study was to investigate the risk and recurrence of early invasive adenocarcinoma of the cervix, and to determine whether non-radical methods of management could be performed. The medical and histopathological records of 50 patients with early invasive adenocarcinoma of the cervix treated at Keio University Hospital between 1993 and 2005 were reviewed, and compared with the literature. The median follow-up period was 64.3 months. The depth of stromal invasion was ≤3 mm in 33 cases and >3 mm, but ≤5 mm in 17 cases. The horizontal spread was ≤7 mm in 25 cases and >7 mm in 25 cases. One of the 33 cases that had tumor volumes of ≤500 mm3, and three of the 17 cases with tumor volumes of >500 mm3 were positive for lymph node metastasis. When our data were combined with previously reported results, statistically significant differences were observed between the tumor volume and the frequency of pelvic lymph node metastasis/the rate of recurrence (p<0.0001). The frequency of pelvic lymph node metastases was significantly higher in the lymphovascular space invasion (LVSI)-positive group than in the LVSI-negative group (p=0.02). No adnexal metastasis or parametrial involvement was noted. Assessment of the depth of stromal invasion, tumor volume, and LVSI is critical for selecting an appropriate therapeutic modality. Non-radical methods of management are considered suitable for patients with LVSI-negative adenocarcinoma of the cervix exhibiting a stromal invasion depth of ≤5 mm and a tumor volume of ≤500 mm3.
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影响因子：
4.7
作者：
ABDULHAYOGLU, G;RICH, WM;DISAIA, PJ
通讯作者：
DISAIA, PJ
影响因子：
4.7
作者：
Covens, A;Kirby, J;Franseen, E
通讯作者：
Franseen, E
DOI：
10.1111/j.1479-828x.1999.tb03123.x
发表时间：
1999-11-01
影响因子：
1.7
作者：
Nicklin, JL;Perrin, LC;Ward, BG
通讯作者：
Ward, BG
DOI：
10.1097/00004347-198909000-00006
发表时间：
1989-09-01
影响因子：
2.4
作者：
ROLLASON, TP;CULLIMORE, J;BRADGATE, MG
通讯作者：
BRADGATE, MG
影响因子：
4.7
作者：
Kasamatsu, T;Okada, S;Ohmi, K
通讯作者：
Ohmi, K